International Research Center for Elements Science, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Org Lett. 2012 Feb 17;14(4):1066-9. doi: 10.1021/ol2031729. Epub 2012 Jan 30.
An efficient and high-yielding cross-coupling reaction of various primary, secondary, and tertiary alkyl chlorides with aryl Grignard reagents was achieved by using catalytic amounts of N-heterocyclic carbene ligands and iron salts. This reaction is a simple and efficient arylation method having applicability to a wide range of industrially abundant chloroalkanes, including polychloroalkanes, which are challenging substrates under conventional cross-coupling conditions.
通过使用催化量的 N-杂环卡宾配体和铁盐，实现了各种伯、仲和叔烷基氯与芳基格氏试剂的高效高产交叉偶联反应。该反应是一种简单有效的芳基化方法，适用于广泛的工业上丰富的氯代烷烃，包括多氯代烷烃，这些在传统交叉偶联条件下是具有挑战性的底物。
