Roemer R A, Dubin W R, Jaffe R, Lipschutz L, Sharon D
Philadelphia Psychiatric Center, PA 19131.
J Clin Psychiatry. 1990 Nov;51(11):473-8.
Twenty-nine patients with major depression, with and without psychosis, were randomly assigned to bilateral conventional electroconvulsive therapy (ECT) or modified multiple monitored ECT (MMECT) limited to two seizure inductions in a session. From pretreatment to after the fourth treatment session, modified MMECT was associated with more rapid amelioration of depressive symptoms on the basis of blindly rated Hamilton Rating Scale for Depression scores. No medical complications occurred. Sixty-two percent of patients in the modified MMECT group had posttreatment confusion, whereas 15% of patients treated with conventional ECT were confused. Modified MMECT appears to confer some clinical advantage over conventional ECT in the treatment of major depression while carrying an increased risk of treatment-related reversible confusion.
29名患有重度抑郁症的患者，伴有或不伴有精神病症状，被随机分配接受双侧传统电休克治疗（ECT）或改良的多次监测电休克治疗（MMECT），后者在一次治疗中限于两次诱发癫痫发作。从治疗前到第四次治疗后，基于盲法评定的汉密尔顿抑郁量表评分，改良MMECT与抑郁症状的更快改善相关。未发生医疗并发症。改良MMECT组62%的患者治疗后出现意识模糊，而接受传统ECT治疗的患者中15%出现意识模糊。在治疗重度抑郁症方面，改良MMECT似乎比传统ECT具有一些临床优势，但与治疗相关的可逆性意识模糊风险增加。
