Budoff P W, Sommers S C
J Reprod Med. 1979 May;22(5):241-7.
A retrospective study was made of 74 women who had received estrogen continuously, cycled with progesterone, for menopausal symptoms over an average 57-month period. Treated patients were compared with control patients from the same private practice. Vabra endometrial aspiration biopsies showed no statistical differences between 25 treated and 28 untreated patients in the frequency of normal, inactive, hyperplastic or neoplastic specimens. The most common finding in the treated group was a secretory response, which suggests that progesterone exerts an antiestrogen effect even when estrogen is given on a continuing basis. There is evidence that the vaginal maturation index in the postmenopausal patient, although helpful in determining the current state of her systemic estrogen activity, may not reflect the effect of estrogen on the endometrium. Estrogen therapy has no absolute predictable correlation with endometrial histology. Thus, the information from routine endometrial curettage is essential to evaluate the status of all treated patients. Among all hormone-treated patients (74), weight decreased over time, blood pressure, blood sugar and cholesterol levels were relatively unchanged, and Papanicolaou smear classes improved.
对74名因更年期症状持续接受雌激素治疗并周期性联合使用孕激素的女性进行了一项回顾性研究，治疗平均持续57个月。将接受治疗的患者与来自同一私人诊所的对照患者进行比较。Vabra子宫内膜抽吸活检显示，25名接受治疗的患者和28名未接受治疗的患者在正常、静止、增生或肿瘤性标本的频率上无统计学差异。治疗组最常见的发现是分泌反应，这表明即使持续给予雌激素，孕激素也会发挥抗雌激素作用。有证据表明，绝经后患者的阴道成熟指数虽然有助于确定其全身雌激素活性的当前状态，但可能无法反映雌激素对子宫内膜的影响。雌激素治疗与子宫内膜组织学没有绝对可预测的相关性。因此，常规子宫内膜刮宫术所得信息对于评估所有接受治疗患者的状况至关重要。在所有接受激素治疗的患者（74名）中，体重随时间下降，血压、血糖和胆固醇水平相对不变，巴氏涂片分级有所改善。
