体力活动受损的老年男性骨骼微结构较差——STRAMBO 研究。
Poor bone microarchitecture in older men with impaired physical performance--the STRAMBO study.
机构信息
INSERM UMR 1033, Université de Lyon, Lyon, France.
出版信息
Osteoporos Int. 2012 Dec;23(12):2785-96. doi: 10.1007/s00198-012-1906-0.
UNLABELLED
In 810 men ≥ 60 years, poor physical performance of lower limbs was associated with lower areal bone mineral density (aBMD) of total hip and poor bone microarchitecture at the distal tibia (assessed by HR-pQCT). Men who reported falls had lower hip aBMD and lower cortical density at the distal tibia.
INTRODUCTION
The aim of this study was to assess the association between bone microarchitecture and physical performance in older men.
METHODS
Volumetric bone mineral density (vBMD) and bone microarchitecture were assessed in 810 men ≥ 60 years at the distal radius and tibia by high resolution pQCT. aBMD was measured at the spine, hip, whole body, and distal radius by dual energy X-ray absorptiometry. Clinical tests included chair stands and tests of static and dynamic balance. We calculated a composite score summarizing abilities and time required to perform the tests.
RESULTS
In multivariable models, men who failed in ≥ one test had lower total hip aBMD than men who accomplished all the tests. They had lower total vBMD (Tt.vBMD), cortical thickness (Ct.Th), trabecular vBMD (Tb.vBMD), and more heterogenous trabecular distribution (Tb.Sp.SD) at the distal tibia (p < 0.05). Men who failed in ≥ two tests had lower aBMD at the total hip, femoral neck, and trochanter as well as lower Tt.vBMD, cortical vBMD (Ct.vBMD), Ct.Th and trabecular number (Tb.N), and higher Tb.Sp.SD at the distal tibia (p < 0.05). Men in the lowest quartile of the composite score had lower aBMD (total hip, distal radius), lower Tb.vBMD and Tb.N at the distal radius, and lower Tt.vBMD, Ct.vBMD, Ct.Th, Tb.vBMD, and Tb.N, and higher Tb.Sp.SD at the distal tibia compared with the highest quartile. In multivariables models, men reporting falls had lower total hip aBMD and lower distal tibia Ct.vBMD (p < 0.01).
CONCLUSION
In older men, poor physical performance is associated with lower hip aBMD and poor bone microarchitecture (mainly at the distal tibia).
不具名
在 810 名年龄在 60 岁以上的男性中，下肢身体表现不佳与全髋关节的骨矿密度（aBMD）较低和胫骨远端的骨微观结构较差（通过 HR-pQCT 评估）有关。报告跌倒的男性髋关节 aBMD 较低，胫骨远端皮质密度较低。
引言
本研究的目的是评估老年人骨微观结构与身体表现之间的关系。
方法
通过高分辨率 pQCT 评估 810 名年龄在 60 岁以上的男性的远端桡骨和胫骨的容积骨密度（vBMD）和骨微观结构。通过双能 X 射线吸收法测量脊柱、髋关节、全身和远端桡骨的 aBMD。临床检查包括椅子站立和静态及动态平衡测试。我们计算了一个综合评分，总结了完成测试所需的能力和时间。
结果
在多变量模型中，未能完成≥1 项测试的男性的全髋关节 aBMD 低于完成所有测试的男性。他们的胫骨远端总 vBMD（Tt.vBMD）、皮质厚度（Ct.Th）、小梁 vBMD（Tb.vBMD）和更不均匀的小梁分布（Tb.Sp.SD）较低（p<0.05）。未能完成≥2 项测试的男性的全髋关节、股骨颈和转子间区的 aBMD 以及 Tt.vBMD、皮质 vBMD（Ct.vBMD）、Ct.Th 和小梁数量（Tb.N）较低，胫骨远端的 Tb.Sp.SD 较高（p<0.05）。综合评分最低四分位数的男性的全髋关节 aBMD（全髋关节、桡骨远端）、桡骨远端的 Tb.vBMD 和 Tb.N 较低，以及全髋关节、桡骨远端的 Tt.vBMD、Ct.vBMD、Ct.Th、Tb.vBMD 和 Tb.N 较低，胫骨远端的 Tb.Sp.SD 较高与最高四分位数相比。在多变量模型中，报告跌倒的男性的全髋关节总 aBMD 和胫骨远端的 Ct.vBMD 较低（p<0.01）。
结论
在老年人中，身体表现不佳与髋关节 aBMD 较低和骨微观结构较差（主要在胫骨远端）有关。
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