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Growth and development: patching up a better pill for GH-deficient women.

作者信息

Birzniece Vita, Ho Ken K Y

出版信息

Nat Rev Endocrinol. 2012 Jan 31;8(4):197-8. doi: 10.1038/nrendo.2012.9.

DOI:10.1038/nrendo.2012.9
PMID:22290355
Abstract
摘要

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Growth and development: patching up a better pill for GH-deficient women.生长与发育：为生长激素缺乏的女性研发更好的药物
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Discontinuation of estrogen replacement therapy in GH-treated hypopituitary women alters androgen status and IGF-I.生长激素治疗的垂体功能减退女性停用雌激素替代疗法会改变雄激素状态和胰岛素样生长因子-I。
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Administration route-dependent effects of estrogens on IGF-I levels during fixed GH replacement in women with hypopituitarism.雌激素对垂体功能减退女性在固定生长激素替代治疗期间胰岛素样生长因子-I水平的给药途径依赖性影响。
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Elevation of E-selectin concentrations may correlate with potential endothelial dysfunction in individuals with hypopituitarism during therapy with growth hormone.在生长激素治疗期间，垂体功能减退患者的E选择素浓度升高可能与潜在的内皮功能障碍相关。
Curr Neurovasc Res. 2007 Feb;4(1):55-62. doi: 10.2174/156720207779940662.
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Effects of short term growth hormone therapy in adult growth hormone deficiency.成人生长激素缺乏症短期生长激素治疗的效果
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Quality of life of growth hormone (GH) deficient young adults during discontinuation and restart of GH therapy.生长激素（GH）缺乏的年轻成年人在生长激素治疗中断和重新开始期间的生活质量。
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[Changes in the lipid profile and thyroid function in adult patients with hypopituitarism after substitutive treatment with growth hormone].
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Hypopituitarism after traumatic brain injury.创伤性脑损伤后的垂体功能减退
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Impact of moderate interval exercise versus supine rest on the pharmacokinetics and pharmacodynamic profiles of subcutaneously administered growth hormone in adult growth hormone deficient patients.中度间歇运动与仰卧休息对成年生长激素缺乏患者皮下注射生长激素的药代动力学和药效学特征的影响。
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Growth Horm IGF Res. 2011 Feb;21(1):1-10. doi: 10.1016/j.ghir.2010.10.005. Epub 2010 Nov 19.

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Hypogonadism as a consequence of craniopharyngioma in female patients: comparison of childhood and adult onset and effects of estrogen replacement therapy.颅咽管瘤导致女性患者性腺功能减退症：儿童期和成年期发病的比较及雌激素替代治疗的影响。
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本文引用的文献

1
Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women.雷洛昔芬和雌激素对生长激素替代治疗的垂体功能减退妇女身体成分的影响。
J Clin Endocrinol Metab. 2012 Mar;97(3):1005-12. doi: 10.1210/jc.2011-2837. Epub 2011 Dec 14.
2
Effects of oral and transdermal estrogen on IGF1, IGFBP3, IGFBP1, serum lipids, and glucose in patients with hypopituitarism during GH treatment: a randomized study.口服和透皮雌激素对生长激素治疗垂体功能减退症患者 IGF1、IGFBP3、IGFBP1、血脂和血糖的影响：一项随机研究。
Eur J Endocrinol. 2012 Feb;166(2):207-13. doi: 10.1530/EJE-11-0560. Epub 2011 Nov 22.
3
Managing Estrogen Therapy in the Pituitary Patient.
垂体疾病患者的雌激素治疗管理
J Endocr Soc. 2023 Apr 20;7(5):bvad051. doi: 10.1210/jendso/bvad051. eCollection 2023 Mar 6.
4
Estrogen and selective estrogen receptor modulators (SERMs) for the treatment of acromegaly: a meta-analysis of published observational studies.用于治疗肢端肥大症的雌激素和选择性雌激素受体调节剂（SERM）：已发表观察性研究的荟萃分析
Pituitary. 2014 Jun;17(3):284-95. doi: 10.1007/s11102-013-0504-2.
Quantification of the adverse effect of ethinylestradiol containing oral contraceptive pills when used in conjunction with growth hormone replacement in routine practice.
在常规实践中，结合生长激素替代疗法使用含炔雌醇的口服避孕药的不良影响的量化。
Clin Endocrinol (Oxf). 2012 May;76(5):729-33. doi: 10.1111/j.1365-2265.2011.04277.x.
4
Estrogen replacement in women of fertile years with hypopituitarism.
J Clin Endocrinol Metab. 2005 Nov;90(11):5964-9. doi: 10.1210/jc.2005-1207. Epub 2005 Aug 9.
5
Comparison of the metabolic effects of raloxifene and oral estrogen in postmenopausal and growth hormone-deficient women.雷洛昔芬与口服雌激素对绝经后及生长激素缺乏女性代谢影响的比较。
J Clin Endocrinol Metab. 2005 Jul;90(7):3897-903. doi: 10.1210/jc.2005-0173. Epub 2005 Apr 26.
6
Estrogen regulation of growth hormone action.雌激素对生长激素作用的调节。
Endocr Rev. 2004 Oct;25(5):693-721. doi: 10.1210/er.2003-0035.
7
Oral estrogen antagonizes the metabolic actions of growth hormone in growth hormone-deficient women.口服雌激素可拮抗生长激素缺乏女性体内生长激素的代谢作用。
Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1191-6. doi: 10.1152/ajpendo.2001.281.6.E1191.
8
Both oral and transdermal estrogen increase growth hormone release in postmenopausal women--a clinical research center study.口服和经皮雌激素均可增加绝经后女性的生长激素释放——一项临床研究中心的研究。
J Clin Endocrinol Metab. 1996 Jun;81(6):2250-6. doi: 10.1210/jcem.81.6.8964860.
9
Comparison of pharmacodynamic properties of various estrogen formulations.不同雌激素制剂的药效学特性比较。
Am J Obstet Gynecol. 1982 Nov 1;144(5):511-8. doi: 10.1016/0002-9378(82)90218-6.
10
Biologic effects of transdermal estradiol.经皮雌二醇的生物学效应。
N Engl J Med. 1986 Jun 19;314(25):1615-20. doi: 10.1056/NEJM198606193142505.