Proteolysis Lab, Molecular Biology Institute of Barcelona, CSIC, Spain.
Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3340-4. doi: 10.1002/anie.201108015. Epub 2012 Jan 31.
I'm your Venus: the crystal structure of the human methylamine-induced form of α(2)-macroglobulin (α(2)M) shows its large central cavity can accommodate two medium-sized proteinases. Twelve major entrances provide access for small substrates to the cavity and the still-active trapped "prey". The structure unveils the molecular basis of the unique "venus flytrap" mechanism of α(2)M.
人亚甲基胺诱导型α（2）-巨球蛋白（α（2）M）的晶体结构显示其大的中心腔可以容纳两个中等大小的蛋白酶。十二个主要入口为小底物进入腔和仍然活跃的捕获“猎物”提供了通道。该结构揭示了α（2）M 独特的“捕蝇草”机制的分子基础。
