倍半萜法呢醇导致类鼻疽伯克霍尔德菌对β-内酰胺类抗生素的敏感性增加。
Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei.
机构信息
Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza-CE, Brazil.
出版信息
Antimicrob Agents Chemother. 2012 Apr;56(4):2198-200. doi: 10.1128/AAC.05885-11. Epub 2012 Jan 30.
Abstract
This study aimed to evaluate the in vitro combination of farnesol and β-lactams against Burkholderia pseudomallei. A total of 12 β-lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 μM. The combination of this compound with β-lactams resulted in statistically significant β-lactam MIC reduction (P ≤ 0.05). This study provides new perspectives for the use of farnesol combined with β-lactam antibiotics against strains of B. pseudomallei.
摘要
本研究旨在评估法尼醇与β-内酰胺类药物联合应用对伯克霍尔德菌的体外效果。根据 CLSI 标准，共检测了 12 株β-内酰胺酶阳性菌株。所有菌株均被法尼醇抑制，MIC 范围为 75-150μM。该化合物与β-内酰胺类药物联合使用可显著降低β-内酰胺类药物的 MIC（P≤0.05）。本研究为法尼醇联合β-内酰胺类抗生素治疗伯克霍尔德菌提供了新的思路。
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