法尼醇对白色念珠菌的活性和毒性取决于生长条件。
Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions.
机构信息
School of Biological Sciences, University of Nebraska-Lincoln, 1901 Vine St., Rm E146, Lincoln, NE 68588-0666, USA.
出版信息
Antimicrob Agents Chemother. 2010 Feb;54(2):940-2. doi: 10.1128/AAC.01214-09. Epub 2009 Nov 23.
Abstract
Farnesol interacts with Candida albicans as both a quorum-sensing molecule and toxic agent, but confusion abounds regarding which conditions promote these distinct responses. Farnesol sensitivity was measured when inoculum cell history and size, temperature, and growth media were altered. Parameters for farnesol tolerance/sensitivity were defined, validating previous studies and identifying new variables, such as energy availability. This study clearly defines what farnesol concentrations are lethal to C. albicans, based on environmental conditions.
摘要
法尼醇既可以作为群体感应分子，也可以作为有毒物质与白色念珠菌相互作用，但对于哪些条件会促进这些不同的反应，存在很多混淆。当改变接种细胞历史和大小、温度和生长培养基时，测量了法尼醇敏感性。定义了法尼醇耐受/敏感性的参数，验证了以前的研究，并确定了新的变量，如能量可用性。这项研究根据环境条件，明确了哪些法尼醇浓度对白色念珠菌是致命的。
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