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2
Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue.法尼醇介导的白色念珠菌酵母生长抑制及二酰基甘油类似物的挽救作用
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Candida albicans Zn Cluster Transcription Factors Tac1 and Znc1 Are Activated by Farnesol To Upregulate a Transcriptional Program Including the Multidrug Efflux Pump .白色念珠菌 Zn 簇转录因子 Tac1 和 Znc1 被法尼醇激活，以上调包括多药外排泵在内的转录程序。
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4
Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione.法尼醇诱导白念珠菌细胞凋亡是通过 Cdr1-p 外排和细胞内谷胱甘肽耗竭介导的。
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本文引用的文献

1
Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans.法呢醇，一种由白念珠菌产生的群体感应分子，其细胞间相互作用。
Future Microbiol. 2009 Dec;4(10):1353-62. doi: 10.2217/fmb.09.98.
2
Farnesol-induced apoptosis in Candida albicans.法尼醇诱导白色念珠菌凋亡。
Antimicrob Agents Chemother. 2009 Jun;53(6):2392-401. doi: 10.1128/AAC.01551-08. Epub 2009 Apr 13.
3
Pseudomonas aeruginosa-Candida albicans interactions: localization and fungal toxicity of a phenazine derivative.铜绿假单胞菌与白色念珠菌的相互作用：一种吩嗪衍生物的定位及真菌毒性
Appl Environ Microbiol. 2009 Jan;75(2):504-13. doi: 10.1128/AEM.01037-08. Epub 2008 Nov 14.
4
Protective effects of farnesol against oral candidiasis in mice.法尼醇对小鼠口腔念珠菌病的保护作用。
Microbiol Immunol. 2008 Jul;52(7):327-33. doi: 10.1111/j.1348-0421.2008.00044.x.
5
Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction.白色念珠菌Tup1参与法尼醇介导的丝状生长诱导抑制作用。
Eukaryot Cell. 2008 Jun;7(6):980-7. doi: 10.1128/EC.00357-07. Epub 2008 Apr 18.
6
Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis.法尼醇和十二烷醇对白色念珠菌Ras1-cAMP信号通路及形态发生调控的影响。
Mol Microbiol. 2008 Jan;67(1):47-62. doi: 10.1111/j.1365-2958.2007.06013.x.
7
Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue.法尼醇介导的白色念珠菌酵母生长抑制及二酰基甘油类似物的挽救作用
Yeast. 2007 Aug;24(8):681-93. doi: 10.1002/yea.1501.
8
Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans.法尼醇对系统性念珠菌病小鼠模型的影响，通过使用白色念珠菌的DPP3基因敲除突变体来确定。
Infect Immun. 2007 Apr;75(4):1609-18. doi: 10.1128/IAI.01182-06. Epub 2007 Feb 5.
9
In vivo and in vitro anaerobic mating in Candida albicans.白色念珠菌的体内和体外厌氧交配
Eukaryot Cell. 2007 Mar;6(3):465-72. doi: 10.1128/EC.00316-06. Epub 2007 Jan 26.
10
Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance.法尼醇对都柏林念珠菌生物膜形成及氟康唑耐药性的影响。
FEMS Yeast Res. 2006 Nov;6(7):1063-73. doi: 10.1111/j.1567-1364.2006.00121.x.

法尼醇对白色念珠菌的活性和毒性取决于生长条件。

Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions.

机构信息

School of Biological Sciences, University of Nebraska-Lincoln, 1901 Vine St., Rm E146, Lincoln, NE 68588-0666, USA.

出版信息

Antimicrob Agents Chemother. 2010 Feb;54(2):940-2. doi: 10.1128/AAC.01214-09. Epub 2009 Nov 23.

DOI:10.1128/AAC.01214-09
PMID:19933803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2812148/
Abstract

Farnesol interacts with Candida albicans as both a quorum-sensing molecule and toxic agent, but confusion abounds regarding which conditions promote these distinct responses. Farnesol sensitivity was measured when inoculum cell history and size, temperature, and growth media were altered. Parameters for farnesol tolerance/sensitivity were defined, validating previous studies and identifying new variables, such as energy availability. This study clearly defines what farnesol concentrations are lethal to C. albicans, based on environmental conditions.

摘要

法尼醇既可以作为群体感应分子，也可以作为有毒物质与白色念珠菌相互作用，但对于哪些条件会促进这些不同的反应，存在很多混淆。当改变接种细胞历史和大小、温度和生长培养基时，测量了法尼醇敏感性。定义了法尼醇耐受/敏感性的参数，验证了以前的研究，并确定了新的变量，如能量可用性。这项研究根据环境条件，明确了哪些法尼醇浓度对白色念珠菌是致命的。