类鼻疽伯克霍尔德菌中A类β-内酰胺酶基因blaA(BPS)的克隆与表达
Cloning and expression of class A beta-lactamase gene blaA(BPS) in Burkholderia pseudomallei.
作者信息
Cheung Terence K M, Ho P L, Woo Patrick C Y, Yuen K Y, Chau P Y
机构信息
Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
出版信息
Antimicrob Agents Chemother. 2002 Apr;46(4):1132-5. doi: 10.1128/AAC.46.4.1132-1135.2002.
Abstract
The beta-lactamase gene blaA(BPS) in Burkholderia pseudomallei was cloned and expressed in Escherichia coli. BPS-1 is a cephalosporinase with an isoelectric point of 7.7. Sequence analysis of BPS-1 revealed conserved motifs typical of class A beta-lactamases and a relationship to the PenA (in B. cepacia) and BlaI (in Yersinia enterocolitica) lineages.
摘要
在类鼻疽伯克霍尔德菌中克隆了β-内酰胺酶基因blaA(BPS)并在大肠杆菌中进行表达。BPS-1是一种等电点为7.7的头孢菌素酶。对BPS-1的序列分析揭示了A类β-内酰胺酶典型的保守基序以及与洋葱伯克霍尔德菌中的PenA和小肠结肠炎耶尔森菌中的BlaI谱系的关系。
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