University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA.
Antimicrob Agents Chemother. 2012 Apr;56(4):2178-80. doi: 10.1128/AAC.05987-11. Epub 2012 Jan 30.
Dosing of cefepime during high blood flow (Qb; 300 ml/min), high dialysate flow (Qd; 3 liter/h) continuous venovenous hemodialysis (CVVHD) is undefined. Six patients on CVVHD had serum and effluent cefepime concentrations measured at 0.5, 1, 2, 6, and 12 h after dosing. Three patients had cefepime concentrations less than the MIC for Pseudomonas aeruginosa. A dose of 2,000 mg every 12 h or 1,000 mg every 8 h may increase time at a therapeutic concentration.
在高血流（Qb；300ml/min）、高透析液流量（Qd；3L/h）行连续性静脉-静脉血液透析（CVVHD）时，头孢吡肟的剂量尚未明确。6 名接受 CVVHD 的患者在给药后 0.5、1、2、6 和 12 小时测量血清和流出液中的头孢吡肟浓度。3 名患者的头孢吡肟浓度低于铜绿假单胞菌的 MIC。每 12 小时给予 2000mg 或每 8 小时给予 1000mg 剂量可能会增加达到治疗浓度的时间。
