Department of Pharmacy Services, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Pharmacy Services, Texas Children's Hospital, Houston, Texas, USA.
Antimicrob Agents Chemother. 2019 Mar 27;63(4). doi: 10.1128/AAC.02006-18. Print 2019 Apr.
This retrospective study included pediatric intensive care unit patients receiving continuous veno-venous hemodiafiltration (CVVHDF) being treated with cefepime. The free drug concentration above one time the MIC (>1×MIC) and four times a presumed MIC (>4×MIC) of 8 μg/ml were calculated. Four patients received doses ranging from 48 to 64 mg/kg of body weight every 6 to 12 h. Three patients achieved 100% >1×MIC, with the fourth patient achieving 98% >1×MIC. Therapeutic drug monitoring should be considered for critically ill patients receiving cefepime on CVVHDF.
这项回顾性研究纳入了接受连续性静脉-静脉血液透析滤过（CVVHDF）治疗并使用头孢吡肟的儿科重症监护病房患者。计算游离药物浓度超过最低抑菌浓度（MIC）1 倍（>1×MIC）和 4 倍（>4×MIC），分别为 8μg/ml 和 32μg/ml。4 名患者每 6 至 12 小时接受 48 至 64mg/kg 的剂量。3 名患者达到 100%>1×MIC，第 4 名患者达到 98%>1×MIC。接受 CVVHDF 治疗头孢吡肟的危重症患者应考虑进行治疗药物监测。
