Institute of Psychiatry, Consultant Psychiatrist, Maudsley Hospital, Denmark Hill, London SE5, UK.
J Psychopharmacol. 1992 Jan;6(2):230-40. doi: 10.1177/026988119200600217.
In the past two decades neurobiological research into schizophrenia has seen a shift of emphasis from the dopaminergic pharmacology of subcortical systems to areas of abnormality inferred from direct studies, i.e. frontal cortex and medial temporal lobe. Recent research has tried to integrate morphological abnormalities with neurochemical and pharmacological data. These integrated approaches have uncovered neurochemical systems other than dopamine which are of importance. This approach has led to greater understanding of neurochemical mechanisms associated with these abnormalities and may provide novel approaches for therapeutic intervention.
在过去的二十年中，精神分裂症的神经生物学研究已经从皮质下系统的多巴胺能药理学转移到直接研究推断的异常区域，即额叶皮层和内侧颞叶。最近的研究试图将形态异常与神经化学和药理学数据相结合。这些综合方法揭示了除多巴胺以外的其他重要神经化学系统。这种方法使我们对与这些异常相关的神经化学机制有了更深入的了解，并可能为治疗干预提供新的方法。
