• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

利妥昔单抗治疗重症皮肤病：靶点、疾病及剂量

Rituximab in severe skin diseases: target, disease, and dose.

作者信息

Bennett Daniel D, Ohanian Maro, Cable Christian T

机构信息

Department of Dermatology, Division of Hematology and Oncology, Scott and White Healthcare, Texas A&M Health Science Center College of Medicine. Temple, TX, USA.

出版信息

Clin Pharmacol. 2010;2:135-41. doi: 10.2147/CPAA.S10929. Epub 2010 Jul 7.

DOI:10.2147/CPAA.S10929
PMID:22291497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3262375/
Abstract

New clinical indications for rituximab seem to appear every day. This review will trace the use of this monoclonal antibody from lymphoid malignancy, to classic autoimmune disease, and specifically severe autoimmune skin diseases. The history leading to different dosing schema with associated pharmacokinetic data will be discussed. A case of livedoid vasculopathy (atrophie blanche) responding to rituximab will illustrate how the response to therapy can help to elucidate previously obscure pathophysiology.

摘要

利妥昔单抗的新临床适应证似乎每天都在出现。本综述将追溯这种单克隆抗体从用于淋巴系统恶性肿瘤，到用于经典自身免疫性疾病，特别是严重自身免疫性皮肤病的应用历程。还将讨论导致不同给药方案及相关药代动力学数据的历史背景。一例对白塞病（白色萎缩）有效的利妥昔单抗病例将说明治疗反应如何有助于阐明此前不明的病理生理学机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26b/3262375/5ffca3949818/cpaa-2-135f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26b/3262375/567703b4ae9c/cpaa-2-135f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26b/3262375/5ffca3949818/cpaa-2-135f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26b/3262375/567703b4ae9c/cpaa-2-135f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26b/3262375/5ffca3949818/cpaa-2-135f2.jpg

相似文献

1
Rituximab in severe skin diseases: target, disease, and dose.利妥昔单抗治疗重症皮肤病：靶点、疾病及剂量
Clin Pharmacol. 2010;2:135-41. doi: 10.2147/CPAA.S10929. Epub 2010 Jul 7.
2
Atrophie Blanche白色萎缩
3
Atrophie blanche: is it associated with venous disease or livedoid vasculopathy?白色萎缩：它与静脉疾病或类脂质渐进性坏死性血管病有关吗？
Adv Skin Wound Care. 2014 Nov;27(11):518-24; quiz 525-6. doi: 10.1097/01.ASW.0000455098.98684.95.
4
Cutaneous polyarteritis nodosa in patients presenting with atrophie blanche.患有白色萎缩的患者的皮肤结节性多动脉炎。
Br J Dermatol. 2003 Apr;148(4):789-94. doi: 10.1046/j.1365-2133.2003.05176.x.
5
Livedoid vasculopathy: an in-depth analysis using a modified Delphi approach.皮肤白细胞碎裂性血管病：应用改良 Delphi 法的深入分析。
J Am Acad Dermatol. 2013 Dec;69(6):1033-1042.e1. doi: 10.1016/j.jaad.2013.07.019. Epub 2013 Sep 9.
6
Livedoid Vasculopathy with Severe Debilitating Neuropathy in a Prior Professional Athlete.一名前职业运动员患有的伴有严重致残性神经病变的萎缩性血管病。
Cureus. 2024 Apr 8;16(4):e57812. doi: 10.7759/cureus.57812. eCollection 2024 Apr.
7
Penile Livedoid Vasculopathy: First Reported Case.阴茎类紫癜性血管病：首例报告病例
Case Rep Vasc Med. 2023 Jul 4;2023:6920383. doi: 10.1155/2023/6920383. eCollection 2023.
8
Clinical, Laboratory, Histopathological and Therapeutic Profile of Livedoid Vasculopathy: A Case Series of 17 Patients.类脂质渐进性坏死性血管病的临床、实验室、组织病理学及治疗概况：17例病例系列研究
Indian Dermatol Online J. 2022 Oct 21;13(6):771-774. doi: 10.4103/idoj.idoj_182_22. eCollection 2022 Nov-Dec.
9
Livedoid vasculopathy with underlying subcutaneous necrotizing venulitis in an asymptomatic hepatitis B virus carrier: is livedoid vasculopathy a true nonvasculitic disorder?无症状乙肝病毒携带者合并潜在皮下坏死性静脉炎的类脂质渐进性坏死性血管病：类脂质渐进性坏死性血管病是真正的非血管炎性疾病吗？
Am J Dermatopathol. 2009 May;31(3):293-6. doi: 10.1097/DAD.0b013e31819560aa.
10
Ulcerative livedoid vasculopathy responding to clopidogrel.对氯吡格雷有反应的溃疡性类脂质渐进性坏死性血管病
JAAD Case Rep. 2018 Feb 3;4(2):203-205. doi: 10.1016/j.jdcr.2017.09.003. eCollection 2018 Mar.

引用本文的文献

1
Livedoid vasculopathy: A review with focus on terminology and pathogenesis.皮肤白细胞碎裂性血管病：术语和发病机制综述。
Vasc Med. 2022 Dec;27(6):593-603. doi: 10.1177/1358863X221130380. Epub 2022 Oct 26.
2
Biological Treatments in Atopic Dermatitis.特应性皮炎的生物治疗
J Clin Med. 2015 Apr 3;4(4):593-613. doi: 10.3390/jcm4040593.

本文引用的文献

1
Rituximab in the treatment of dermatomyositis and other inflammatory myopathies. A report of 4 cases and review of the literature.利妥昔单抗治疗皮肌炎和其他炎性肌病。4 例报告及文献复习。
Clin Exp Rheumatol. 2009 Nov-Dec;27(6):1009-16.
2
Is there a role for B-cell depletion as therapy for scleroderma? A case report and review of the literature.硬皮病的 B 细胞耗竭治疗是否有效？病例报告及文献复习。
Semin Arthritis Rheum. 2010 Oct;40(2):127-36. doi: 10.1016/j.semarthrit.2009.09.003. Epub 2009 Dec 11.
3
Livedoid vasculopathy: thrombotic or inflammatory disease?
皮肤白细胞碎裂性血管病：血栓性还是炎症性疾病？
Clin Exp Dermatol. 2010 Oct;35(7):693-8. doi: 10.1111/j.1365-2230.2009.03732.x.
4
Successful combination of Rituximab and plasma exchange in the treatment of cryoglobulinemic vasculitis with skin ulcers: a case report.利妥昔单抗与血浆置换联合成功治疗伴皮肤溃疡的冷球蛋白血症性血管炎：一例报告
Cases J. 2009 Jul 6;2:7859. doi: 10.4076/1757-1626-2-7859.
5
A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis.一项关于利妥昔单抗治疗难治性抗中性粒细胞胞浆抗体相关性血管炎的多中心调查。
Arthritis Rheum. 2009 Jul;60(7):2156-68. doi: 10.1002/art.24637.
6
Rituximab therapy for severe refractory chronic Henoch-Schönlein purpura.利妥昔单抗治疗重度难治性慢性过敏性紫癜。
J Pediatr. 2009 Jul;155(1):136-9. doi: 10.1016/j.jpeds.2008.12.049.
7
Epidermal barrier dysfunction in atopic dermatitis.特应性皮炎中的表皮屏障功能障碍。
J Invest Dermatol. 2009 Aug;129(8):1892-908. doi: 10.1038/jid.2009.133. Epub 2009 Jun 4.
8
Livedoid vasculopathy with underlying subcutaneous necrotizing venulitis in an asymptomatic hepatitis B virus carrier: is livedoid vasculopathy a true nonvasculitic disorder?无症状乙肝病毒携带者合并潜在皮下坏死性静脉炎的类脂质渐进性坏死性血管病：类脂质渐进性坏死性血管病是真正的非血管炎性疾病吗？
Am J Dermatopathol. 2009 May;31(3):293-6. doi: 10.1097/DAD.0b013e31819560aa.
9
Rituximab-induced vasculitis: A case report and review of the medical published work.利妥昔单抗诱导的血管炎：一例病例报告及已发表医学文献综述
J Dermatol. 2009 May;36(5):284-7. doi: 10.1111/j.1346-8138.2009.00639.x.
10
Refractory urticarial vasculitis responsive to anti-B-cell therapy.
Br J Dermatol. 2009 Feb;160(2):470-2. doi: 10.1111/j.1365-2133.2008.08990.x. Epub 2008 Dec 11.