Arora Rajesh, Gupta Damodar, Chawla Raman, Sagar Ravinder, Sharma Ashok, Kumar Raj, Prasad Jagdish, Singh Surinder, Samanta Namita, Sharma Rakesh Kumar
Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, Brig. SK Mazumdar Road, Delhi-110 054, India.
Phytother Res. 2005 Jan;19(1):1-22. doi: 10.1002/ptr.1605.
The development of radioprotective agents has been the subject of intense research in view of their potential for use within a radiation environment, such as space exploration, radiotherapy and even nuclear war. However, no ideal, safe synthetic radioprotectors are available to date, so the search for alternative sources, including plants, has been on going for several decades. In Ayurveda, the traditional Indian system of medicine, several plants have been used to treat free radical-mediated ailments and, therefore, it is logical to expect that such plants may also render some protection against radiation damage. A systematic screening approach can provide leads to identifying potential new candidate drugs from plant sources, for mitigation of radiation injury. This article reviews some of the most promising plants, and their bioactive principles, that are widely used in traditional systems of medicine, and which have rendered significant radioprotection in both in vitro and in vivo model systems. Plants and their constituents with pharmacological activities that may be relevant to amelioration of radiation-mediated damage, including antiemetic, antiinflammatory, antioxidant, cell proliferative, wound healing and haemopoietic stimulatories are also discussed.
鉴于辐射防护剂在太空探索、放射治疗甚至核战争等辐射环境中的潜在用途，其研发一直是深入研究的课题。然而，迄今为止尚无理想、安全的合成辐射防护剂，因此寻找包括植物在内的替代来源的研究已经持续了几十年。在印度传统医学阿育吠陀中，有几种植物被用于治疗自由基介导的疾病，因此可以合理推测，这些植物也可能对辐射损伤起到一定的防护作用。系统的筛选方法有助于从植物来源中识别出潜在的新型候选药物，以减轻辐射损伤。本文综述了一些最有前景的植物及其生物活性成分，这些植物在传统医学体系中广泛使用，并在体外和体内模型系统中都表现出显著的辐射防护作用。还讨论了具有可能与改善辐射介导损伤相关药理活性的植物及其成分，包括止吐、抗炎、抗氧化、细胞增殖、伤口愈合和造血刺激作用。
