特应性疾病中的表皮屏障功能障碍和皮肤致敏。
Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases.
机构信息
Department of Dermatology, Keio University School of Medicine, Shinanomachi 35, Shinjuku, Tokyo 160-8582, Japan.
出版信息
J Clin Invest. 2012 Feb;122(2):440-7. doi: 10.1172/JCI57416. Epub 2012 Feb 1.
Abstract
Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies, cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators' attention on epidermal barrier dysfunction as a causative mechanism. The skin's barrier function has three elements: the stratum corneum (air-liquid barrier), tight junctions (liquid-liquid barrier), and the Langerhans cell network (immunological barrier). Clarification of the molecular events underpinning epidermal barrier function and dysfunction should lead to a better understanding of the pathophysiological mechanisms of atopic diseases.
摘要
经典的特应性皮炎常伴有哮喘、变应性鼻炎和食物过敏，统称为特应性疾病。最近发现，丝聚合蛋白基因突变是特应性疾病的易感因素，这重新引起了研究人员对表皮屏障功能障碍作为致病机制的关注。皮肤的屏障功能有三个要素：角质层（气-液相屏障）、紧密连接（液-液相屏障）和朗格汉斯细胞网络（免疫屏障）。阐明支持表皮屏障功能和功能障碍的分子事件，应能更好地理解特应性疾病的病理生理机制。
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