剖析毛发再生中的隆起现象。
Dissecting the bulge in hair regeneration.
机构信息
Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
出版信息
J Clin Invest. 2012 Feb;122(2):448-54. doi: 10.1172/JCI57414. Epub 2012 Feb 1.
Abstract
The adult hair follicle houses stem cells that govern the cyclical growth and differentiation of multiple cell types that collectively produce a pigmented hair. Recent studies have revealed that hair follicle stem cells are heterogeneous and dynamic throughout the hair cycle. Moreover, interactions between heterologous stem cells, including both epithelial and melanocyte stem cells, within the hair follicle are just now being explored. This review will describe how recent findings have expanded our understanding of the development, organization, and regeneration of hair follicle stem cells. At a basic level, this review is intended to help construct a reference point to integrate the surge of studies on the molecular mechanisms that regulate these cells.
摘要
成人毛囊中存在干细胞，这些干细胞调控着多种细胞类型的周期性生长和分化，这些细胞共同产生有色素的毛发。最近的研究揭示了毛囊干细胞在整个毛发生长周期中具有异质性和动态性。此外，毛囊内异质干细胞（包括上皮干细胞和黑素细胞干细胞）之间的相互作用才刚刚开始被探索。这篇综述将描述最近的发现如何扩展了我们对毛囊干细胞的发育、组织和再生的理解。在基础层面上，这篇综述旨在帮助构建一个参考点，以整合调控这些细胞的分子机制的大量研究。
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本文引用的文献
1
Targeting the Hedgehog pathway in cancer.针对癌症中的 Hedgehog 通路。
Ther Adv Med Oncol. 2010 Jul;2(4):237-50. doi: 10.1177/1758834010366430.
2
Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration.Wnt 在上皮和黑素细胞干细胞中的协调激活启动有色素的毛发再生。
Cell. 2011 Jun 10;145(6):941-955. doi: 10.1016/j.cell.2011.05.004.
3
Current status of therapeutic targeting of developmental signalling pathways in oncology.肿瘤治疗中发育信号通路的治疗靶向的现状。
Curr Pharm Biotechnol. 2012 Sep;13(11):2184-220. doi: 10.2174/138920112802502114.
4
Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells.神经源性 sonic hedgehog 为毛囊干细胞定义了一个能够成为表皮干细胞的小生境。
Cell Stem Cell. 2011 May 6;8(5):552-65. doi: 10.1016/j.stem.2011.02.021.
5
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations.小鼠的基底细胞癌起源于毛囊干细胞和多个上皮祖细胞群体。
J Clin Invest. 2011 May;121(5):1768-81. doi: 10.1172/JCI46307. Epub 2011 Apr 25.
6
Hair follicle stem cells provide a functional niche for melanocyte stem cells.毛囊干细胞为黑素干细胞提供了一个功能性龛位。
Cell Stem Cell. 2011 Feb 4;8(2):177-87. doi: 10.1016/j.stem.2010.11.029.
7
Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice.基底细胞癌起源于 Ptch1(+/-) 小鼠的毛囊干细胞。
Cancer Cell. 2011 Jan 18;19(1):114-24. doi: 10.1016/j.ccr.2010.11.007. Epub 2011 Jan 6.
8
Dynamics between stem cells, niche, and progeny in the hair follicle.毛囊中的干细胞、龛和祖细胞之间的动力学。
Cell. 2011 Jan 7;144(1):92-105. doi: 10.1016/j.cell.2010.11.049.
9
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J Clin Invest. 2011 Feb;121(2):613-22. doi: 10.1172/JCI44478. Epub 2011 Jan 4.
10
Action of methylcholanthrene on certain scars of the skin in mice.甲基胆蒽对小鼠皮肤某些瘢痕的作用。
Cancer Res. 1946 Apr;6:183-8.
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