真皮乳头：毛囊发育和再生过程中上皮干细胞和祖细胞的一个具有指导作用的微环境。
The dermal papilla: an instructive niche for epithelial stem and progenitor cells in development and regeneration of the hair follicle.
作者信息
Morgan Bruce A
机构信息
Department of Dermatology, Harvard Medical School and Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129.
出版信息
Cold Spring Harb Perspect Med. 2014 Jul 1;4(7):a015180. doi: 10.1101/cshperspect.a015180.
Abstract
The dermal papilla (DP) of the hair follicle is both a chemical and physical niche for epithelial progenitor cells that regenerate the cycling portion of the hair follicle and generate the hair shaft. Here, we review experiments that revealed the importance of the DP in regulating the characteristics of the hair shaft and frequency of hair follicle regeneration. More recent work showed that the size of this niche is dynamic and actively regulated and reduction in DP cell number per follicle is sufficient to cause hair thinning and loss. The formation of the DP during follicle neogenesis provides a context to contemplate the mechanisms that maintain DP size and the potential to exploit these processes for hair preservation or restoration.
摘要
毛囊的真皮乳头（DP）对于上皮祖细胞而言既是化学微环境也是物理微环境，这些上皮祖细胞可使毛囊的循环部分再生并生成毛干。在此，我们回顾了一些实验，这些实验揭示了DP在调节毛干特征和毛囊再生频率方面的重要性。最近的研究表明，这个微环境的大小是动态的且受到积极调控，每个毛囊中DP细胞数量的减少足以导致头发变细和脱落。在毛囊新生过程中DP的形成提供了一个背景，可据此思考维持DP大小的机制以及利用这些过程来保持或恢复头发的可能性。
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