从角质形成细胞到癌症：皮肤鳞状细胞癌的发病机制和建模。
From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma.
机构信息
Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
出版信息
J Clin Invest. 2012 Feb;122(2):464-72. doi: 10.1172/JCI57415. Epub 2012 Feb 1.
Abstract
Cutaneous squamous cell carcinoma (cSCC) is the second most common human cancer with over 250,000 new cases annually in the US and is second in incidence only to basal cell carcinoma. cSCC typically manifests as a spectrum of progressively advanced malignancies, ranging from a precursor actinic keratosis (AK) to squamous cell carcinoma (SCC) in situ (SCCIS), invasive cSCC, and finally metastatic SCC. In this Review we discuss clinical and molecular parameters used to define this range of cutaneous neoplasia and integrate these with the multiple experimental approaches used to study this disease. Insights gained from modeling cSCCs have suggested innovative therapeutic targets for treating these lesions.
摘要
皮肤鳞状细胞癌（cSCC）是第二大常见的人类癌症，每年在美国有超过 250,000 例新发病例，发病率仅次于基底细胞癌。cSCC 通常表现为一系列逐渐进展的恶性肿瘤，从前期光化性角化病（AK）到原位鳞状细胞癌（SCCIS）、浸润性 cSCC，最后是转移性 SCC。在这篇综述中，我们讨论了用于定义这一系列皮肤肿瘤的临床和分子参数，并将这些参数与用于研究这种疾病的多种实验方法相结合。从模拟 cSCC 中获得的见解为治疗这些病变提供了创新的治疗靶点。
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