Frol'kis R A, Likhtenshteĭn I E, Smirnova I P, Tsiomik V A
Kardiologiia. 1979 May;19(5):73-8.
The effect of curantil on the values of energy metabolism in different parts of the myocardium was studied on dogs with experimental myocardial infarction. Tissue respiration, the activity of Krebs' cycle enzymes, cytochrome oxidase, pentose phosphate cycle and glycolysis, and the content of glycogen and adenyl components were studied. It was established that curantil has a positive effect on energy processes, particularly in myocardial areas not involved in ischemia. It is suggested that activation of tissue oxidation enzymes, which improves oxygen utilization and increases ATP production, is among the mechanisms of the curantil effect. It is noted that curantil stimulates the synthesis of glycogen and inhibits its decomposition. The accumulation in the myocardium of AMP, the precursor of adenosine possessing a marked coronarolytic effect, is an important aspect of the drug's action.
在患有实验性心肌梗死的狗身上，研究了库兰特（curantil）对心肌不同部位能量代谢值的影响。研究了组织呼吸、三羧酸循环酶、细胞色素氧化酶、磷酸戊糖循环和糖酵解的活性，以及糖原和腺苷成分的含量。已确定库兰特对能量过程有积极作用，特别是在未发生缺血的心肌区域。有人认为，激活组织氧化酶，改善氧利用并增加三磷酸腺苷（ATP）生成，是库兰特作用机制之一。值得注意的是，库兰特刺激糖原合成并抑制其分解。腺苷的前体——腺苷一磷酸（AMP）在心肌中的积累具有显著的冠脉舒张作用，这是该药物作用的一个重要方面。
