Otolaryngology and Head & Neck Surgery Research Centre, Tehran University of Medical Sciences, Iran.
Pathol Res Pract. 2012 Feb 15;208(2):100-3. doi: 10.1016/j.prp.2011.12.009. Epub 2012 Jan 30.
Survivin expression is correlated with suppression of apoptosis in human solid tumors. A polymorphism at position -31 (G/C) (rs 9904341) has been associated with cancer risk in several studies. We evaluated the correlation of this polymorphism with the risk of papillary thyroid carcinoma (PTC) in an Irananian population. The cases consisted of patients with PTC (n=123) and normal controls, composed of non-related healthy people (n=131). The frequency of GC or CC genotype in patients with PTC was significantly higher than in the controls [GC+CC vs GG, p=0.02 OR; 1.7, 95%CI (1.05-3.04)]. There was a significant difference between patients with more aggressive clinical manifestations, including lymphatic involvement compared to the controls [GC+CC vs GG, p=0.0006, OR; 3.7, 95%CI (1.6-9.2)]. The presence of C allele was significantly associated with the presence of more profound manifestations, including lymph node involvement, vascular involvement and multifocality.
Survivin 表达与人类实体肿瘤中细胞凋亡的抑制有关。在几项研究中，位于-31 位（G/C）（rs9904341）的多态性与癌症风险相关。我们在伊朗人群中评估了这种多态性与甲状腺乳头状癌（PTC）风险的相关性。病例包括 PTC 患者（n=123）和正常对照组，由无亲缘关系的健康人组成（n=131）。PTC 患者中 GC 或 CC 基因型的频率明显高于对照组[GC+CC 比 GG，p=0.02 OR；1.7，95%CI（1.05-3.04）]。与对照组相比，具有更具侵袭性临床表现的患者（包括淋巴浸润）之间存在显著差异[GC+CC 比 GG，p=0.0006，OR；3.7，95%CI（1.6-9.2）]。C 等位基因的存在与更明显的表现（包括淋巴结浸润、血管浸润和多灶性）显著相关。
