Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan.
Nanotechnology. 2012 Mar 2;23(8):085102. doi: 10.1088/0957-4484/23/8/085102. Epub 2012 Feb 1.
Although zinc oxide nanoparticles (ZnONPs) have been applied in nanotechnology, their kinetics and tissue distribution in vivo are unknown. Here we compared the kinetics and tissue distribution of 10 nm (65)ZnONPs, 71 nm (65)ZnONPs and (65)Zn(NO(3))(2) in mice after intravenous injection. The areas under the curves and the half-lives in the second compartment of (65)Zn(NO(3))(2) were greater than those of (65)ZnONPs; the kinetic parameters were similar for both (65)ZnONPs. However, the tissue distributions for the three forms were different. ZnONPs preferentially accumulated in the liver and spleen at 24 h. At day 28, (65)Zn concentration was highest in bone and the proportion of recovered (65)Zn radioactivity was highest in the carcass; these had the same ranking, 10 nm (65)ZnONPs > 71 nm (65)ZnONPs> (65)Zn(NO(3))(2). Although more than 80% of the 10 nm (65)ZnONPs had been excreted by day 28, greater amounts of the 10 nm (65)ZnONPs than the 71 nm (65)ZnONPs or (65)Zn(NO(3))(2) had accumulated in other organs (brain, lung, heart and kidneys). Zn ions seem to have a longer half-life in the plasma, but ZnONPs show greater tissue accumulation. Although the size of the ZnONPs had no obvious effect on the kinetics, nevertheless the smaller ZnONPs tended to accumulate preferentially in some organs.
尽管氧化锌纳米粒子（ZnONPs）已被应用于纳米技术，但它们在体内的动力学和组织分布情况尚不清楚。在此，我们比较了静脉注射后 10nm（65）ZnONPs、71nm（65）ZnONPs 和（65）Zn（NO3）2在小鼠体内的动力学和组织分布情况。（65）Zn（NO3）2的曲线下面积和第二隔室的半衰期大于（65）ZnONPs；两种（65）ZnONPs 的动力学参数相似。然而，三种形式的组织分布情况不同。ZnONPs 在 24 小时时优先在肝脏和脾脏中积累。在第 28 天，（65）Zn 浓度在骨骼中最高，回收的（65）Zn 放射性比例在尸体中最高；这三者的顺序相同，10nm（65）ZnONPs>71nm（65）ZnONPs>（65）Zn（NO3）2。尽管到第 28 天，超过 80%的 10nm（65）ZnONPs 已被排出，但 10nm（65）ZnONPs 的积累量大于 71nm（65）ZnONPs 或（65）Zn（NO3）2，在其他器官（脑、肺、心和肾）中积累更多。Zn 离子在血浆中的半衰期似乎更长，但 ZnONPs 显示出更大的组织积累。尽管 ZnONPs 的尺寸对动力学没有明显影响，但较小的 ZnONPs 倾向于优先在某些器官中积累。
