时间对大鼠和小鼠组织中氧化锌纳米颗粒分布影响的评估：一项系统综述
Evaluation of the effect of time on the distribution of zinc oxide nanoparticles in tissues of rats and mice: a systematic review.
作者信息
Chen Aijie, Feng Xiaoli, Sun Ting, Zhang Yanli, An Shengli, Shao Longquan
机构信息
Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, People's Republic of China.
Medical Centre of Stomatology, The First Affiliated Hospital of Jinan University, 613 Huangpu Avenue West, Guangzhou, People's Republic of China.
出版信息
IET Nanobiotechnol. 2016 Jun;10(3):97-106. doi: 10.1049/iet-nbt.2015.0006.
Abstract
To evaluate the time effect on the distribution of zinc oxide nanoparticles (ZnO NPs) in tissues from rats and mice, a search on the PubMed, Embase, SpringerLink, Scopus, Science Direct, Cochrane, CNKI, Wanfang, and vip databases up to September 2014 was performed, followed by screening, data extraction, and quality assessment. Thirteen studies were included. At 24 h, Zn content was mainly distributed in the liver, kidney, and lung. At ≥7 days, Zn content was mainly distributed in the liver, kidney, lung, and brain. ZnO NPs are readily deposited in tissues. Furthermore, as time increases, Zn content decreases in the liver and kidney, but increases in the brain.
摘要
为评估时间对大鼠和小鼠组织中氧化锌纳米颗粒（ZnO NPs）分布的影响，我们检索了截至2014年9月的PubMed、Embase、SpringerLink、Scopus、Science Direct、Cochrane、中国知网（CNKI）、万方和维普数据库，随后进行筛选、数据提取和质量评估。共纳入13项研究。在24小时时，锌含量主要分布在肝脏、肾脏和肺中。在≥7天时，锌含量主要分布在肝脏、肾脏、肺和脑中。ZnO NPs易于在组织中沉积。此外，随着时间的增加，肝脏和肾脏中的锌含量降低，但脑中的锌含量增加。
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本文引用的文献
1
Toxicity of zinc oxide nanoparticles in rats treated by two different routes: single intravenous injection and single oral administration.
J Toxicol Environ Health A. 2015;78(4):226-43. doi: 10.1080/15287394.2014.949949.
2
Zinc oxide nanoparticles for revolutionizing agriculture: synthesis and applications.
ScientificWorldJournal. 2014;2014:925494. doi: 10.1155/2014/925494. Epub 2014 Nov 11.
3
Toxicological mode of action of ZnO nanoparticles: Impact on immune cells.
Mol Immunol. 2015 Feb;63(2):184-92. doi: 10.1016/j.molimm.2014.08.001. Epub 2014 Sep 2.
4
Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats.
Part Fibre Toxicol. 2014 Jul 3;11:30. doi: 10.1186/1743-8977-11-30.
5
Effects of dietary zinc oxide nanoparticles on growth performance and antioxidative status in broilers.
Biol Trace Elem Res. 2014 Sep;160(3):361-7. doi: 10.1007/s12011-014-0052-2. Epub 2014 Jun 29.
6
Short- and long-term distribution and toxicity of gold nanoparticles in the rat after a single-dose intravenous administration.
Nanomedicine. 2014 Nov;10(8):1757-66. doi: 10.1016/j.nano.2014.06.005. Epub 2014 Jun 15.
7
Size-dependent clearance of gold nanoparticles from lungs of Sprague-Dawley rats after short-term inhalation exposure.
Arch Toxicol. 2015 Jul;89(7):1083-94. doi: 10.1007/s00204-014-1292-9. Epub 2014 Jun 17.
8
Accumulation and toxicity of CuO and ZnO nanoparticles through waterborne and dietary exposure of goldfish (Carassius auratus).
Environ Toxicol. 2015 Jan;30(1):119-28. doi: 10.1002/tox.22002. Epub 2014 May 24.
9
Dose ranging, expanded acute toxicity and safety pharmacology studies for intravenously administered functionalized graphene nanoparticle formulations.
Biomaterials. 2014 Aug;35(25):7022-31. doi: 10.1016/j.biomaterials.2014.04.066. Epub 2014 May 20.
10
Nanoparticle oxygen delivery to the ischemic heart.
Perfusion. 2014 Nov;29(6):539-43. doi: 10.1177/0267659114534290. Epub 2014 May 6.
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