Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
Biol Pharm Bull. 2012;35(2):260-4. doi: 10.1248/bpb.35.260.
Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including anti-inflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3 ± 4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.
金纳米粒子 (GNPs) 已被报道具有多种生物学效应，包括抗炎和抗氧化活性。通过测定胶原和乙二醛的体外糖化反应混合物的程度，研究了 GNPs 在胶原中的抑制乙二醛衍生的晚期糖基化终产物 (glycol-AGEs) 形成的作用，胶原是人类真皮的主要蛋白质成分。与未经处理的糖化对照相比，经 GNP 处理的胶原显示出明显较少的糖化（56.3 ± 4.2%）。此外，在胶原格子模型中，经 GNP 处理的糖化显著减少了模型系统中 AGEs 的分布。总之，这些结果表明 GNPs 具有用于预防糖化诱导的皮肤老化的潜力。
