Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
BMC Biol. 2012 Jan 31;10:7. doi: 10.1186/1741-7007-10-7.
Microglia are the abundant, resident myeloid cells of the central nervous system (CNS) that become rapidly activated in response to injury or inflammation. While most studies of microglia focus on this phenomenon, little is known about the function of 'resting' microglia, which possess fine, branching cellular processes. Biber and colleagues, in a recent paper in Journal of Neuroinflammation, report that ramified microglia can limit excitotoxicity, an important insight for understanding mechanisms that limit neuron death in CNS disease.
小胶质细胞是中枢神经系统 (CNS) 中丰富的、固有髓系细胞，它们在受到损伤或炎症时会迅速被激活。虽然大多数关于小胶质细胞的研究都集中在这一现象上，但对于“静息”小胶质细胞的功能却知之甚少，“静息”小胶质细胞具有精细的分支状细胞突起。Biber 及其同事在最近发表在《神经炎症杂志》上的一篇论文中报告称，有树突状的小胶质细胞可以限制兴奋性毒性，这一重要发现有助于理解中枢神经系统疾病中限制神经元死亡的机制。
