对感染克氏锥虫（巴西株）早期的脂肪组织反应。
Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain).
机构信息
Department of Pathology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA.
出版信息
J Infect Dis. 2012 Mar 1;205(5):830-40. doi: 10.1093/infdis/jir840. Epub 2012 Jan 31.
Abstract
Brown adipose tissue (BAT) and white adipose tissue (WAT) and adipocytes are targets of Trypanosoma cruzi infection. Adipose tissue obtained from CD-1 mice 15 days after infection, an early stage of infection revealed a high parasite load. There was a significant increase in macrophages in infected adipose tissue and a reduction in lipid accumulation, adipocyte size, and fat mass and increased expression of lipolytic enzymes. Infection increased levels of Toll-like receptor (TLR) 4 and TLR9 and in the expression of components of the mitogen-activated protein kinase pathway. Protein and messenger RNA (mRNA) levels of peroxisome proliferator-activated receptor γ were increased in WAT, whereas protein and mRNA levels of adiponectin were significantly reduced in BAT and WAT. The mRNA levels of cytokines, chemokines, and their receptors were increased. Nuclear Factor Kappa B levels were increased in BAT, whereas Iκκ-γ levels increased in WAT. Adipose tissue is an early target of T. cruzi infection.
摘要
棕色脂肪组织 (BAT) 和白色脂肪组织 (WAT) 以及脂肪细胞是克氏锥虫感染的靶标。在感染后 15 天的 CD-1 小鼠的脂肪组织中，即感染的早期阶段，发现寄生虫负荷很高。感染的脂肪组织中巨噬细胞显著增加，脂质积累减少，脂肪细胞大小、脂肪质量减少，脂肪分解酶表达增加。感染增加了 Toll 样受体 (TLR) 4 和 TLR9 的水平，以及丝裂原活化蛋白激酶途径的组成部分的表达。过氧化物酶体增殖物激活受体 γ 的蛋白和信使 RNA (mRNA) 水平在 WAT 中增加，而 BAT 和 WAT 中的脂联素的蛋白和 mRNA 水平显著降低。细胞因子、趋化因子及其受体的 mRNA 水平增加。核因子 Kappa B 水平在 BAT 中增加，而 Iκκ-γ 水平在 WAT 中增加。脂肪组织是克氏锥虫感染的早期靶标。
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