Pessoa Vitória França Dos Santos, Hecht Mariana, Nitz Nadjar, Hagström Luciana
Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, University of Brasilia, Brasília 70910-900, Brazil.
Faculty of Physical Education, University of Brasília, Brasília 70910-900, Brazil.
Pathogens. 2025 Mar 31;14(4):339. doi: 10.3390/pathogens14040339.
Chagas disease (CD), caused by the protozoan , is a serious public health issue with high morbidity and mortality rates. Approximately 7 million people are infected, mostly in Latin America. The pathogenesis is multifactorial and poorly elucidated, particularly regarding the role of adipose tissue (AT). This review aims to explore the complex relationship between and AT, focusing on the possible role of this tissue in CD, as well as to explore the impact of diet on the progression of the disease. infects adipocytes, affecting their function. Chronic infection alters adipose physiology, contributing to systemic inflammation and metabolic disturbances. Adipokines are dysregulated, while markers of inflammation and oxidative stress increase within AT during CD. Additionally, the immune response and clinical aspects of CD may be influenced by the host's diet. High-fat diets (HFDs) impact parasite burden and cardiac pathology in murine models. The complex interaction among infection, AT dysfunction, and dietary factors underscore the complexity of CD pathogenesis. Despite accumulating evidence suggesting the role of AT in CD, further research is needed to elucidate its clinical implications. Understanding the bidirectional relationship between AT and infection may offer insights into disease progression and potential therapeutic targets, highlighting the importance of considering adipose physiology in CD management strategies.
恰加斯病（CD）由原生动物引起，是一个严重的公共卫生问题，发病率和死亡率都很高。大约有700万人受到感染，主要集中在拉丁美洲。其发病机制是多因素的，且尚未完全阐明，尤其是关于脂肪组织（AT）的作用。本综述旨在探讨[原文此处缺失相关内容]与AT之间的复杂关系，重点关注该组织在CD中的可能作用，以及探讨饮食对疾病进展的影响。[原文此处缺失相关内容]感染脂肪细胞，影响其功能。慢性感染会改变脂肪生理，导致全身炎症和代谢紊乱。脂肪因子失调，而在CD期间AT内炎症和氧化应激标志物会增加。此外，CD的免疫反应和临床方面可能会受到宿主饮食的影响。在小鼠模型中，高脂饮食（HFDs）会影响寄生虫负荷和心脏病理。[原文此处缺失相关内容]感染、AT功能障碍和饮食因素之间的复杂相互作用凸显了CD发病机制的复杂性。尽管有越来越多的证据表明AT在CD中的作用，但仍需要进一步研究以阐明其临床意义。了解AT与[原文此处缺失相关内容]感染之间的双向关系可能会为疾病进展和潜在治疗靶点提供见解，突出了在CD管理策略中考虑脂肪生理的重要性。
