Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69121 Heidelberg, Germany.
Mutagenesis. 2012 Mar;27(2):197-204. doi: 10.1093/mutage/ger061.
Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the 'ancestral-susceptibility model' can be reasonably applied to nutrition-related complex diseases such as obesity. The work in hand shortly discusses whether the ancestral-susceptibility model can also be applied to CRC as a nutrition-related complex disease.
每年大约有 100 万例新的结直肠癌 (CRC) 病例被诊断出来，全球约有 50 万人因此癌症而死亡。CRC 发病率的已知差异主要归因于饮食和其他环境因素的差异，其中包括与营养相关的复杂疾病（如肥胖和 II 型糖尿病）。在过去的几年中，人们已经意识到，在考虑 CRC 的风险时，环境危险因素可以通过遗传成分来补充。例如，已知许多多态性与肥胖的风险增加有关，而肥胖是 CRC 的一个风险因素。多项研究表明，“祖先易感性模型”可以合理地应用于肥胖等与营养相关的复杂疾病。目前的工作简要讨论了该祖先易感性模型是否也可以应用于 CRC 作为一种与营养相关的复杂疾病。
