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B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.IGH-BCL2 和 MYC 同时重排的 B 细胞淋巴瘤是具有侵袭性的肿瘤，其临床和病理特征与 Burkitt 淋巴瘤和弥漫性大 B 细胞淋巴瘤不同。
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[Survival of patients with primary central nervous system diffuse large B-cell lymphoma: impact of gene aberrations and protein overexpression of bcl-2 and C-MYC, and selection of chemotherapy regimens].[原发性中枢神经系统弥漫性大B细胞淋巴瘤患者的生存：bcl-2和C-MYC基因畸变及蛋白过表达的影响以及化疗方案的选择]
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MYC, BCL2, and BCL6 rearrangements in primary central nervous system lymphoma of large B cell type.原发性中枢神经系统弥漫性大 B 细胞淋巴瘤中 MYC、BCL2 和 BCL6 重排。
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[B-cell lymphomas with concurrent myc and bcl-2/IgH or bcl-6 translocations].伴有myc与bcl-2/IgH或bcl-6同时易位的B细胞淋巴瘤
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Double-hit B-cell lymphomas with BCL6 and MYC translocations are aggressive, frequently extranodal lymphomas distinct from BCL2 double-hit B-cell lymphomas.具有 BCL6 和 MYC 易位的双打击 B 细胞淋巴瘤是侵袭性的，常为结外淋巴瘤，与 BCL2 双打击 B 细胞淋巴瘤不同。
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Contribution of immunophenotype to the investigation and differential diagnosis of Burkitt lymphoma, double-hit high-grade B-cell lymphoma, and single-hit MYC-rearranged diffuse large B-cell lymphoma.免疫表型对 Burkitt 淋巴瘤、双打击高级别 B 细胞淋巴瘤和单打击 MYC 重排弥漫性大 B 细胞淋巴瘤的研究和鉴别诊断的贡献。
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Central nervous system infiltration of a multiple cytokine-producing double-hit B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma with CC chemokine receptor 7 expression.一例多细胞因子分泌的双打击B细胞淋巴瘤的中枢神经系统浸润，无法分类，具有弥漫性大B细胞淋巴瘤和伯基特淋巴瘤之间的中间特征，并表达CC趋化因子受体7 。
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A fatal back pain: report of two cases of diffuse large B cell/Burkitt-like nervous system lymphoma.致命性背痛：两例弥漫性大B细胞/伯基特样神经系统淋巴瘤病例报告
Neurol Sci. 2019 Mar;40(3):645-647. doi: 10.1007/s10072-018-3631-8. Epub 2018 Nov 1.
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Primary CNS Burkitt Lymphoma: A Case Report of a 55-Year-Old Cerebral Palsy Patient.原发性中枢神经系统伯基特淋巴瘤：一名55岁脑瘫患者的病例报告。
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Primary central nervous system germinal center B-like diffuse large B-cell lymphoma: a case report.原发性中枢神经系统生发中心B样弥漫性大B细胞淋巴瘤：一例报告
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T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma.以原发性中枢神经系统淋巴瘤形式出现的富于T细胞/组织细胞的大B细胞淋巴瘤
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Primary burkitt lymphoma of the fourth ventricle in an immunocompetent young patient.一名免疫功能正常的年轻患者发生的第四脑室原发性伯基特淋巴瘤。
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本文引用的文献

1
Selective central nervous system tropism of primary central nervous system lymphoma.原发性中枢神经系统淋巴瘤的选择性中枢神经系统嗜性
Int J Clin Exp Pathol. 2010 Oct 8;3(8):763-7.
2
Double-hit B-cell lymphomas.双打击 B 细胞淋巴瘤。
Blood. 2011 Feb 24;117(8):2319-31. doi: 10.1182/blood-2010-09-297879. Epub 2010 Nov 30.
3
Differential gene expression in central nervous system lymphoma.中枢神经系统淋巴瘤中的差异基因表达
Blood. 2009 Jan 1;113(1):266-7; author reply 267-8. doi: 10.1182/blood-2008-04-152835.
4
Pathway analysis of primary central nervous system lymphoma.原发性中枢神经系统淋巴瘤的通路分析
Blood. 2008 Mar 15;111(6):3200-10. doi: 10.1182/blood-2007-10-119099. Epub 2008 Jan 9.
5
A uniform activated B-cell-like immunophenotype might explain the poor prognosis of primary central nervous system lymphomas: analysis of 83 cases.一致的活化B细胞样免疫表型可能解释原发性中枢神经系统淋巴瘤的不良预后：83例分析
Blood. 2006 Jan 1;107(1):190-6. doi: 10.1182/blood-2005-03-1024. Epub 2005 Sep 8.
6
New highly sensitive fluorescence in situ hybridization method to detect PML/RARA fusion in acute promyelocytic leukemia.用于检测急性早幼粒细胞白血病中PML/RARA融合基因的新型高灵敏度荧光原位杂交方法。
Cancer Genet Cytogenet. 2003 Sep;145(2):144-51. doi: 10.1016/s0165-4608(03)00061-x.
7
B lymphocytes in the normal brain: contrasts with HIV-associated lymphoid infiltrates and lymphomas.正常大脑中的B淋巴细胞：与HIV相关淋巴浸润和淋巴瘤的对比。
Brain. 2003 May;126(Pt 5):1058-67. doi: 10.1093/brain/awg118.

具有介于弥漫性大B细胞淋巴瘤和伯基特淋巴瘤之间特征的原发性中枢神经系统B细胞淋巴瘤。

Primary central nervous system B cell lymphoma with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma.

作者信息

Jiang Liuyan, Li Zhimin, Finn Laura E, Personnet David A, Edenfield Brandy, Foran James M, Jaeckle Kurt A, Reimer Ronald, Menke David M, Ketterling Rhett P, Tun Han W

机构信息

Department of Pathology, Mayo Clinic, Jacksonville, Florida 32224, USA.

出版信息

Int J Clin Exp Pathol. 2012;5(1):72-6. Epub 2012 Jan 1.

PMID:22295149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3267488/
Abstract

B cell lymphoma with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (DLBCL/BL) is a new lymphoma entity which is recognized in the current World Health Organization (WHO) classification (2008). We report a case of a primary central nervous system lymphoma (PCNSL) with findings consistent with DLBCL/BL. It is characterized by a very aggressive clinical course, and a widespread multifocal involvement of the CNS. Our case shows that a DLBCL/BL can manifest in the CNS alone without any systemic involvement.

摘要

具有弥漫性大B细胞淋巴瘤和伯基特淋巴瘤（DLBCL/BL）之间特征的B细胞淋巴瘤是一种新的淋巴瘤实体，在当前世界卫生组织（WHO）分类（2008年）中得到认可。我们报告一例原发性中枢神经系统淋巴瘤（PCNSL），其表现与DLBCL/BL一致。它的特点是临床病程非常侵袭性，且中枢神经系统广泛多灶性受累。我们的病例表明，DLBCL/BL可单独在中枢神经系统表现，而无任何全身受累。