Advani Pooja, Starr Jason, Swaika Abhisek, Jiang Liuyan, Qiu Yushi, Li Zhimin, Tun Han W
Division of Hematology and Oncology, Department of Internal Medicine, Mayo Clinic , Jacksonville, FL, USA.
Division of Hematology and Oncology, Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA; Cancer Specialists of North Florida, Jacksonville, FL, USA.
Rare Tumors. 2015 Dec 29;7(4):6084. doi: 10.4081/rt.2015.6084.
Primary central nervous system (PCNSL) lymphoma is an aggressive extranodal non-Hodgkin lymphoma, and most cases are classified as diffuse large B-cell lymphoma (DLBCL) by histology. T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL) represents a distinct subtype of diffuse large B-cell lymphoma and is characterized by the presence of scattered large neoplastic B-cells in a background of abundant T-cells and histiocytes. This is in contrast to the dense perivascular cuffing of neoplastic B-cells in classic DLBCL. T-cell/histiocyte-rich large B-cell lymphoma should be considered in PCNSL cases in which neoplastic B-cells are sparse and scattered. Immunohistochemistry will help identify the B-cells and surrounding infiltrate rich in Tlymphocytes and histiocytes. Future studies exploring the biology of TCRLBCL and the crosstalk between the neoplastic cells and the surrounding inflammatory infiltrate may provide exciting prospects for future therapies for TCRLBCL.
原发性中枢神经系统（PCNSL）淋巴瘤是一种侵袭性结外非霍奇金淋巴瘤，大多数病例在组织学上被归类为弥漫性大B细胞淋巴瘤（DLBCL）。富于T细胞/组织细胞的大B细胞淋巴瘤（TCRLBCL）是弥漫性大B细胞淋巴瘤的一种独特亚型，其特征是在大量T细胞和组织细胞背景中存在散在的大的肿瘤性B细胞。这与经典DLBCL中肿瘤性B细胞的致密血管周围套袖状浸润形成对比。在肿瘤性B细胞稀疏且散在的PCNSL病例中应考虑富于T细胞/组织细胞的大B细胞淋巴瘤。免疫组织化学将有助于识别B细胞以及富含T淋巴细胞和组织细胞的周围浸润。未来探索TCRLBCL生物学以及肿瘤细胞与周围炎性浸润之间相互作用的研究可能为TCRLBCL的未来治疗提供令人兴奋的前景。
