结肠淋巴上皮瘤样癌
Lymphoepithelioma-like carcinoma of the colon.
作者信息
Delaney David, Chetty Runjan
机构信息
Department of Cellular Pathology and Nuffield Department of Clinical Laboratory Science, Biomedical Research Centre Oxford, Oxford University Hospitals Trust, University of Oxford United Kingdom.
出版信息
Int J Clin Exp Pathol. 2012;5(1):105-9. Epub 2012 Jan 5.
Abstract
An 85-year old female had a polypoid tumour in the sigmoid colon that histologically conformed to a lymphoepithelioma-like (LEL) carcinoma. The tumour was arranged in cords, chains, clusters and microalveoli of pleomorphic, irregular cells set within a dense intratumoral lymphocytic stroma. The tumour was EBV-negative and showed loss of MLH-1 and PMS-2 mismatch repair proteins. The patient did not fulfil the criteria for HNPCC. Only 5 other cases of primary colonic LEL carcinoma have been described previously and only one case appears to have an unequivocal association with EBV. In addition, one of the cases was encountered in a HNPCC patient. This is an unusual morphologic variant of a microsatellite unstable tumour with a LEL pattern, not associated with EBV.
摘要
一位85岁女性在乙状结肠有一个息肉样肿瘤，组织学上符合淋巴上皮瘤样（LEL）癌。肿瘤由多形性、不规则细胞形成的条索、链状、簇状和微腺泡组成，位于致密的肿瘤内淋巴细胞间质中。肿瘤EBV阴性，显示MLH-1和PMS-2错配修复蛋白缺失。该患者不符合HNPCC的标准。此前仅描述过另外5例原发性结肠LEL癌病例，只有1例似乎与EBV有明确关联。此外，其中1例病例见于一名HNPCC患者。这是一种具有LEL模式的微卫星不稳定肿瘤的不寻常形态学变异型，与EBV无关。
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