a Ahfad University for Women , Omdurman , Sudan.
b Weill Cornell Medicine - Qatar , Cornell University, Qatar Foundation - Education City , Doha , Qatar.
Hum Vaccin Immunother. 2019;15(3):603-610. doi: 10.1080/21645515.2018.1543525. Epub 2018 Nov 15.
Epstein-Barr virus (EBV) is a well-characterized oncovirus, associated with several malignancies. The complex and heterogeneous nature of colorectal cancer (CRC) has led to many epidemiological causal associations with CRC. However, a direct causal link between microbial infections and CRC has not been established yet. Our review indicates that the current evidence for the presence and role in EBV in CRC is insufficient and contradictory. The design of the analyzed studies, sample size as well as methodology used for EBV detection varied markedly and consequently may not lead to meaningful conclusions. The presence of EBV in other colorectal tumors (lymphomas, smooth muscle tumors) is in line with their status at other anatomic locations and may have therapeutic implications with EBV-specific vaccines. On the other hand, studies exploring EBV in colorectal adenoma-carcinoma sequence and its molecular genetic characteristics are largely missing and may significantly contribute to a better understanding of the role of EBV in CRC.
EB 病毒（EBV）是一种特征明确的致癌病毒，与多种恶性肿瘤相关。结直肠癌（CRC）的复杂性和异质性导致了许多与 CRC 的流行病学因果关联。然而，微生物感染与 CRC 之间的直接因果关系尚未确定。我们的综述表明，目前 EBV 在 CRC 中的存在及其作用的证据不足且相互矛盾。分析研究的设计、用于 EBV 检测的样本量以及所使用的方法差异很大，因此可能无法得出有意义的结论。EBV 在其他结直肠肿瘤（淋巴瘤、平滑肌肿瘤）中的存在与其在其他解剖部位的状态一致，并且可能对 EBV 特异性疫苗具有治疗意义。另一方面，探索 EBV 在结直肠腺瘤-癌序列及其分子遗传学特征中的作用的研究还很少，这可能会极大地促进对 EBV 在 CRC 中的作用的理解。
