Chen Junxiang, Cheng Meichu, Yi Li, Jiang Chang-bin
Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, China.
Asian Pac J Cancer Prev. 2011;12(9):2163-6.
To study the potential role of cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms in the risk of renal cell cancer in Chinese.
A total of 181 pathologically-proven renal cancers and 350 controls from the second Xiangya Hospital in Changsha were collected during the period from May 2007 to December 2010. CYP1A1 genetic polymorphisms were genotyped using PCRRFLP. Unconditional logistic regression analysis was performed to analyze their relationship with risk of RCC.
Individuals with Val/Val genotypes had a significantly increased risk of RCC compared those with CYP1A1 IIe/IIe (OR=1.69, 95%CI=1.03-2.85). We also found CYP1A1 Wt/Vt and Vt/Vt to confer a significantly greater risk than CYP1A1 Wt/Wt (Wt/Vt: OR=2.14, 95%CI=1.24-3.45; Vt/Vt: OR=1.78, 95%CI=1.31-3.96). In smokers, a high increase risk of RCC was observed in those with CYP1A1 Val allele and Vt allele (Val allele: OR=2.13, 95%CI=1.40-2.57; Vt allele: OR=3.75, 95%CI=2.43-6.79), but no other significant interactions were found.
Our study found suggestive evidence that CYP1A1 polymorphisms may play an important role in the etiology of RCC. Cigarette smoking may increase the susceptibility to RCC carcinogenesis in individuals with a high-risk genotype.
研究细胞色素P450 1A1（CYP1A1）基因多态性在中国肾细胞癌发生风险中的潜在作用。
2007年5月至2010年12月期间，收集了长沙中南大学湘雅二医院181例经病理证实的肾癌患者和350例对照者。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对CYP1A1基因多态性进行基因分型。采用非条件logistic回归分析方法分析其与肾细胞癌发生风险的关系。
与携带CYP1A1 IIe/IIe基因型的个体相比，携带Val/Val基因型的个体患肾细胞癌的风险显著增加（OR=1.69，95%CI=1.03-2.85）。我们还发现，与携带CYP1A1 Wt/Wt基因型的个体相比，携带CYP1A1 Wt/Vt和Vt/Vt基因型的个体患肾细胞癌的风险显著增加（Wt/Vt：OR=2.14，95%CI=1.24-3.45；Vt/Vt：OR=1.78，95%CI=1.31-3.96）。在吸烟者中，携带CYP1A1 Val等位基因和Vt等位基因的个体患肾细胞癌的风险显著增加（Val等位基因：OR=2.13，95%CI=1.40-2.57；Vt等位基因：OR=3.75，95%CI=2.43-6.79），但未发现其他显著的交互作用。
本研究发现提示性证据，表明CYP1A1基因多态性可能在肾细胞癌的病因学中起重要作用。吸烟可能增加高危基因型个体患肾细胞癌的易感性。
