2003 - 2005年泰国儿童癌症发病率与生存率：泰国儿科肿瘤学组的研究

Childhood cancer incidence and survival 2003-2005, Thailand: study from the Thai Pediatric Oncology Group.

作者信息

Wiangnon Surapon, Veerakul Gavivann, Nuchprayoon Issarang, Seksarn Panya, Hongeng Suradej, Krutvecho Triroj, Sripaiboonkij Nintita

机构信息

Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand.

出版信息

Asian Pac J Cancer Prev. 2011;12(9):2215-20.

PMID:22296359

Abstract

BACKGROUND

Previous population-based incidences of childhood cancer in Thailand were achieved by extrapolating from data limited to a small number of cancer registries, not from the whole country. In addition, survival of childhood cancer patients is often described in specialized hospitals and/or institutions, but not in the general population.

METHODS

All children aged 0-15 years who were newly diagnosed as having cancer were registered from 18 treatment centers during 2003-5 and classified into 12 diagnostic groups according to the International Classification of Childhood Cancer. Incidences were calculated by a standard method and survival was investigated using the ThaiPOG (Thai Pediatric Oncology Group) population-based registration data. Overall survival was calculated by the Kaplan Meier method.

RESULTS

In the study period (2003-5) 2,792 newly diagnosed cases of childhood cancer were registered, with mean and median ages of 6.5 (SD=0.13) and 5.0 (0-14) years, respectively. The age-peak was between 1 and 4 years and the age-standardized rate (ASR) was 74.9 per million. Leukemia was the most common cancer (N=1421, ASR 38.1) followed by lymphoma (N=266, ASR 6.4) and neoplasms of the central nervous system (CNS, N=246, ASR 6.3). The follow-up duration totaled 101,250 months. The death rate was 1.11 per 100 person-months (95%CI: 1.02 -1.20). The 5-year overall survival was 54.9% (95%CI: 53.0%-56.9%) for all cancers. The respective, 5-year overall survival for (1) acute lymphoblastic leukemia (ALL), (2) acute non-lymphoblastic leukemia (ANLL), (3) lymphoma, (4) retinoblastoma, (5) renal tumors, (6) liver tumors, (7) germ cell tumors, (8) CNS tumors, (9) neuroblastoma, (10) soft tissue tumors and (11) bone tumors were (1) 64.5%, (2) 35.1%, (3) 59.5%, (4) 73.1%, (5) 70.4%, (6) 44.5%, (7) 70.6%, (8) 41.7%, (9) 33.6%, (10) 50.1%, and (11) 33.7%.

CONCLUSIONS

The incidence of childhood cancer is lower than in western countries. Respective overall survival for ALL, lymphoma, renal tumors, liver tumors, retinoblastoma, soft tissue tumors is lower than those reported in developed countries while for CNS tumors, neuroblastoma and germ cell tumors the figures are comparable.

摘要

背景

泰国以往基于人群的儿童癌症发病率是通过对少数癌症登记处的数据进行推断得出的，而非来自全国范围。此外，儿童癌症患者的生存率通常是在专科医院和/或机构中描述的，而非普通人群中的情况。

方法

2003年至2005年期间，从18个治疗中心登记了所有新诊断为患有癌症的0至15岁儿童，并根据国际儿童癌症分类将其分为12个诊断组。发病率通过标准方法计算，生存率使用泰国儿科肿瘤学组（ThaiPOG）基于人群的登记数据进行调查。总生存率通过Kaplan-Meier方法计算。

结果

在研究期间（2003年至2005年），登记了2792例新诊断的儿童癌症病例，平均年龄和中位年龄分别为6.5岁（标准差=0.13）和5.0岁（0至14岁）。年龄高峰在1至4岁之间，年龄标准化率（ASR）为每百万74.9例。白血病是最常见的癌症（N=1421，ASR 38.1），其次是淋巴瘤（N=266，ASR 6.4）和中枢神经系统（CNS）肿瘤（N=246，ASR 6.3）。随访总时长为101250个月。死亡率为每100人月1.11例（95%可信区间：1.02 - 1.20）。所有癌症的5年总生存率为54.9%（95%可信区间：53.0% - 56.9%）。（1）急性淋巴细胞白血病（ALL）、（2）急性非淋巴细胞白血病（ANLL）、（3）淋巴瘤、（4）视网膜母细胞瘤、（5）肾肿瘤、（6）肝肿瘤、（7）生殖细胞肿瘤、（8）CNS肿瘤、（9）神经母细胞瘤、（10）软组织肿瘤和（11）骨肿瘤各自的5年总生存率分别为（1）64.5%、（2）35.1%、（3）59.5%、（4）73.1%、（5）70.4%、（6）44.5%、（7）70.6%、（8）41.7%、（9）33.6%、（10）50.1%和（11）33.7%。