埃塞俄比亚亚的斯亚贝巴儿童癌症的发病率和模式（2012-2017 年）。

Incidence and pattern of childhood cancer in Addis Ababa, Ethiopia (2012-2017).

机构信息

Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT- Africa), Addis Ababa University, Addis Ababa, Ethiopia.

School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

出版信息

BMC Cancer. 2023 Dec 21;23(1):1261. doi: 10.1186/s12885-023-11765-7.

DOI:10.1186/s12885-023-11765-7

PMID:38129792

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10734044/

Abstract

BACKGROUND

Cancer is becoming a major public health problem globally and a leading cause of death in children in developed countries. However, little is known about the epidemiology of childhood cancer in Ethiopia. This study, therefore, assessed childhood cancer incidence patterns in Addis Ababa using the Addis Ababa city population-based cancer registry data from 2012 to 2017.

METHODS

Invasive cancer cases diagnosed in ages 0-14 years from 2012 to 2017 were obtained from the Addis Ababa City population-based Cancer Registry. Cases were grouped according to the International Classification of Childhood Cancer, 3rd edition (ICCC-3) based on morphology and primary anatomic site. Age-standardized incidence rates (ASR) were calculated by the direct method using the world standard population.

RESULTS

The overall average annual incidence rate during 2012-2017 in children was 84.6 cases per million, with rates higher in boys (98.97 per million) than in girls (69.7 per million). By age, incidence rates per million increased from 70.8 cases in ages 0-4 years to 88.4 cases in ages 5-9 years to 110.0 cases 10-14 years. Leukaemia was the most common childhood cancer in both boys (29.1%) and girls (26.8%), followed by lymphoma in boys (24.7%) and renal tumours (13.1%) in girls. The overall cancer incidence rate decreased from 87.02 per million in 2012 to 51.07 per million in 2017.

CONCLUSION

The burden of childhood cancer is considerably high in Addis Ababa. The observed distribution of childhood cancer in Addis Ababa differs from other African countries. This study highlights the need for further research and understanding of the variations in cancer patterns and risk factors across the region.

摘要

背景

癌症在全球范围内正成为一个主要的公共卫生问题，也是发达国家儿童死亡的主要原因。然而，人们对埃塞俄比亚儿童癌症的流行病学知之甚少。因此，本研究利用 2012 年至 2017 年亚的斯亚贝巴市基于人群的癌症登记数据，评估了亚的斯亚贝巴儿童癌症的发病模式。

方法

从 2012 年至 2017 年，从亚的斯亚贝巴市基于人群的癌症登记处获得了年龄在 0-14 岁之间被诊断患有侵袭性癌症的病例。根据国际儿童癌症分类第 3 版（ICCC-3），根据形态和主要解剖部位对病例进行分组。使用世界标准人口通过直接法计算年龄标准化发病率（ASR）。

结果

2012-2017 年期间，儿童的总体平均年发病率为 84.6 例/百万人，男孩（98.97 例/百万人）的发病率高于女孩（69.7 例/百万人）。按年龄计算，每百万人口的发病率从 0-4 岁的 70.8 例增加到 5-9 岁的 88.4 例，再增加到 10-14 岁的 110.0 例。白血病是男孩（29.1%）和女孩（26.8%）中最常见的儿童癌症，其次是男孩中的淋巴瘤（24.7%）和女孩中的肾肿瘤（13.1%）。总体癌症发病率从 2012 年的 87.02 例/百万人下降到 2017 年的 51.07 例/百万人。