Huang Guo-Liang, Guo Hong-Qiang, Yu Chun-Yan, Liu Xing-Yan, Li Bin-Bin, Wu Jing-Jing, He Zhi-Wei
Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China.
Asian Pac J Cancer Prev. 2011;12(9):2329-33.
Previous studies on the association between X-ray repair cross-complementing protein 1 (XRCC1) polymorphisms and nasopharyngeal carcinoma (NPC) risk showed inconsistent results. The aim of this study was to evaluate the effects of XRCC1 variants on NPC risk.
A meta-analysis was performed with all eligible studies covering a total of 1,341 cases and 1,425 controls for the Arg194Trp polymorphism, 1,260 cases and 1,207 controls for the Arg280His polymorphism, and 1,644 cases and 1,678 controls for the Arg399Gln polymorphism.
No associations was found between Arg194Trp and Arg280His polymorphisms with NPC risk under all contrast models (co-dominant, dominant, and recessive models). However a deleterious effect of the 399Gln genotype was observed under the co-dominant model (Gln/Gln versus Arg/Arg, OR = 1.30, 95% CI : 1.01-1.69, P = 0.04). Under the recessive model (Gln/Gln versus Arg/Arg+Arg/Gln), the P value was marginally significant (OR = 1.28, 95% CI : 1.00-1.65, P = 0.05). However, the effect of the 399Gln genotype on NPC became non-significant after excluding one study from the meta-analysis because of departure from Hardy-Weinberg equilibrium.
No associations were found between Arg194Trp and Arg280His polymorphisms with NPC risk, whereas the Arg399Gln genotype was associated with increased risk.
先前关于X射线修复交叉互补蛋白1（XRCC1）基因多态性与鼻咽癌（NPC）风险之间关联的研究结果并不一致。本研究旨在评估XRCC1基因变异对NPC风险的影响。
对所有符合条件的研究进行荟萃分析，其中涉及1341例病例和1425例对照的精氨酸194色氨酸多态性、1260例病例和1207例对照的精氨酸280组氨酸多态性，以及1644例病例和1678例对照的精氨酸399谷氨酰胺多态性。
在所有对比模型（共显性、显性和隐性模型）下，未发现精氨酸194色氨酸和精氨酸280组氨酸多态性与NPC风险之间存在关联。然而，在共显性模型下观察到399谷氨酰胺基因型具有有害作用（谷氨酰胺/谷氨酰胺与精氨酸/精氨酸相比，OR = 1.30，95%CI：1.01 - 1.69，P = 0.04）。在隐性模型（谷氨酰胺/谷氨酰胺与精氨酸/精氨酸 + 精氨酸/谷氨酰胺相比）下，P值接近显著（OR = 1.28，95%CI：1.00 - 1.65，P = 0.05）。然而，由于偏离哈迪 - 温伯格平衡，在荟萃分析中排除一项研究后，399谷氨酰胺基因型对NPC的影响变得不显著。
未发现精氨酸194色氨酸和精氨酸280组氨酸多态性与NPC风险之间存在关联，而精氨酸399谷氨酰胺基因型与风险增加有关。
