Kim Jeongseon, Park Sohee, Nam Byung-Ho
Cancer Epidemiology Branch, Division of Cancer Epidemiology and Management, Research Institute, National Cancer Center, Goyang, Korea.
Asian Pac J Cancer Prev. 2011;12(9):2371-6.
To date, there have been few prospective cohort studies that have investigated the association between meat consumption and the risk of colorectal cancer (CRC) in Asian countries. A large, population-based cohort study was conducted to assess the effect of the frequency of meat consumption on the risk of CRC in Korean adults.
The participants were Korean government employees, school faculty members, and their unemployed dependents, aged 30-80 years, who underwent health examinations between 1996 and 1997. In 2003, information on CRC incidence was obtained during the 6-7 year follow-up period. The final data analysis included 2,248,129 study subjects. The hazard ratio (HR) and 95% confidence interval (CI) of the HR were estimated using the Cox proportional hazards regression model.
During the follow-up period, CRC occurred in 4,501 men and 1,943 women (64.19 and 36.34 for age-standardized incidence rates per 100,000 person-years, respectively). In the total population, the estimated HRs and 95% CI for meat consumption of 2-3 times per week and more than 4 times per week compared with consumption of less than once per week were 1.06 (1.01-1.12) and 1.23 (1.13-1.35), respectively. In men only and women only groups, the HRs (95% CI) for consumption of more than 4 times per week compared with consumption of less than once per week were 1.13 (1.02-1.26) and 1.42 (1.21-1.66), respectively.
The present findings suggest that frequency of meat consumption is positively associated with the risk of CRC.
迄今为止，在亚洲国家，很少有前瞻性队列研究调查肉类消费与结直肠癌（CRC）风险之间的关联。开展了一项大型的基于人群的队列研究，以评估肉类消费频率对韩国成年人患CRC风险的影响。
参与者为年龄在30至80岁之间的韩国政府雇员、学校教职员工及其无业家属，他们在1996年至1997年期间接受了健康检查。2003年，在6至7年的随访期内获得了CRC发病率信息。最终数据分析包括2248129名研究对象。使用Cox比例风险回归模型估计风险比（HR）及其95%置信区间（CI）。
在随访期间，4501名男性和1943名女性发生了CRC（年龄标准化发病率分别为每10万人年64.19和36.34）。在总人口中，每周食用肉类2至3次和每周食用超过4次与每周食用少于1次相比，估计的HR及其95%CI分别为1.06（1.01 - 1.12）和1.23（1.13 - 1.35）。仅在男性组和仅在女性组中，每周食用超过4次与每周食用少于1次相比，HR（95%CI）分别为1.13（1.02 - 1.26）和1.42（1.21 - 1.66）。
目前的研究结果表明，肉类消费频率与CRC风险呈正相关。
