Cancer Epidemiology Branch, Division of Cancer Epidemiology and Management, National Cancer Center Research Institute, Goyang-si, Gyeonggi-do, South Korea.
Am J Clin Nutr. 2010 May;91(5):1289-93. doi: 10.3945/ajcn.2009.28732. Epub 2010 Mar 10.
Although the incidence of gastric cancer is declining, it remains the most common cancer in Korea. There have been discrepancies in epidemiologic studies regarding a causal relation between highly salted food and the risk of gastric cancer.
The aim of this study was to assess the effect of salt preference on the incidence of gastric cancer in Korean adults through a population-based, prospective cohort study.
Participants were Korean government employees, school faculty members, and their unemployed dependents, aged 30-80 y, who underwent health examinations between 1996 and 1997. In 2003, information on the gastric cancer incidence in these participants was obtained during the 6-7-y follow-up period. The final data analysis included 2,248,129 study subjects. The hazard ratio (HR) and 95% CI of the HR were estimated by using the Cox proportional hazards regression model.
The age-standardized incidence rates per 100,000 person-years for the overall total population, men only, and women only were 97.64, 136.03, and 52.90, respectively. The Cox proportional hazards regression model, with adjustment for possible confounding factors, showed evidence of an increased risk of gastric cancer with salt preference. The HRs were 1.10 (95% CI: 1.04, 1.16) and 1.10 (95% CI: 1.03, 1.17) for the overall total population and men only, respectively.
The current findings suggest that salt preference has a marginal positive association with a risk of gastric cancer.
尽管胃癌的发病率正在下降，但它仍是韩国最常见的癌症。关于高盐食物与胃癌风险之间的因果关系，流行病学研究结果存在差异。
本研究旨在通过一项基于人群的前瞻性队列研究，评估韩国成年人对盐的偏好对胃癌发病率的影响。
参与者为韩国政府雇员、学校教职员工及其失业家属，年龄在 30-80 岁之间，他们于 1996 年至 1997 年期间接受了健康检查。在 2003 年，在 6-7 年的随访期间，获得了这些参与者的胃癌发病率信息。最终数据分析包括 2248129 名研究对象。使用 Cox 比例风险回归模型估计了 HR 及其 95%CI。
总体人群、男性和女性的年龄标准化发病率（每 100000 人年）分别为 97.64、136.03 和 52.90。Cox 比例风险回归模型，调整了可能的混杂因素，表明对盐的偏好与胃癌风险增加有关。总体人群和男性的 HR 分别为 1.10（95%CI：1.04，1.16）和 1.10（95%CI：1.03，1.17）。
目前的研究结果表明，对盐的偏好与胃癌风险呈轻微正相关。
