载脂蛋白 J 多态性 rs11136000 与中国汉族人群晚发性阿尔茨海默病的关联研究。
Association study of clusterin polymorphism rs11136000 with late onset Alzheimer's disease in Chinese Han population.
机构信息
Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to the Shanghai Jiao Tong University School of Medicine, China.
出版信息
Am J Alzheimers Dis Other Demen. 2011 Dec;26(8):627-30. doi: 10.1177/1533317511432735. Epub 2012 Jan 31.
Abstract
OBJECTIVE
We conducted a case-control study to investigate whether clusterin polymorphism (rs11136000) was associated with late-onset Alzheimer's disease in Chinese Han population.
METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOEε4 in 127 patients with late-onset Alzheimer's disease and 143 control individuals. Previous published data from other Chinese samples was also included for further meta-analysis.
RESULTS
APOEε4 was demonstrated to increase the risk of Alzheimer's disease in Chinese population (odds ratio = 2.35, 95% confidence interval: 1.40-3.96). There is no significant association between clusterin rs11136000 with late-onset sporadic AD in our small cohort. However, meta-analysis revealed significant allele and genotype differences between Alzheimer's disease and controls following a recessive model.
CONCLUSION
Clusterin (rs11136000) was associated with Alzheimer's disease in Chinese Han population.
摘要
目的
我们进行了一项病例对照研究，以调查簇蛋白多态性（rs11136000）是否与中国汉族人群的晚发性阿尔茨海默病有关。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）法检测 127 例晚发性阿尔茨海默病患者和 143 例对照个体的基因型 rs11136000 和 APOEε4。还纳入了其他中国人群的已发表数据进行进一步的荟萃分析。
结果
APOEε4 在中国人群中增加了阿尔茨海默病的风险（比值比=2.35，95%置信区间：1.40-3.96）。在我们的小队列中，簇蛋白 rs11136000 与散发性晚发性 AD 之间没有显著关联。然而，荟萃分析显示，在隐性模型下，阿尔茨海默病患者与对照组之间存在等位基因和基因型差异。
结论
簇蛋白（rs11136000）与中国汉族人群的阿尔茨海默病有关。
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