Center for Primary Health Care Research, Lund University/Region Skåne, Clinical Research Centre, Floor 11, Building 28, Entrance 72, Skåne University Hospital, 205 02 Malmö, Sweden.
Eur J Cancer. 2012 Aug;48(12):1875-83. doi: 10.1016/j.ejca.2012.01.005. Epub 2012 Jan 30.
Stroke is common in cancer patients, but risk estimates for different cancer sites/types have not been determined. The aim of this nationwide study was to examine whether there is an association between cancer and first hospitalisation for haemorrhagic or ischaemic stroke.
All 820,491 individuals in Sweden with a diagnosis of cancer between 1st January 1987 and 31st December 2008 were followed for first hospitalisation for haemorrhagic or ischaemic stroke. The reference population was the total population of Sweden without cancer. Standardised incidence ratios (SIRs) for haemorrhagic and ischaemic strokes were calculated.
Overall risk of haemorrhagic stroke and ischaemic stroke during the first 6 months after diagnosis of cancer was 2.2 (95% confidence interval (CI)= 2.0-2.3) and 1.6 (CI = 1.5-1.6), respectively. For 18 and 20 of the 34 cancers studied, respectively, risk of haemorrhagic and ischaemic strokes was increased. Overall stroke risk decreased rapidly, but remained elevated, even 10+years after diagnosis of cancer 1.2 (CI = 1.1-1.3) for haemorrhagic stroke and 1.1 (CI = 1.1-1.2) for ischaemic stroke. The risk of stroke was highest during the first 6 months after diagnosis of cancer of the nervous system (29 (CI = 25-34) for haemorrhagic stroke and 4.1 (CI = 3.4-4.8) for ischaemic stroke)) or leukaemia (13 (CI = 10-16) for haemorrhagic stroke and 3.0 (CI = 2.5-3.7) for ischaemic stroke)). Metastasis was associated with an increased risk of haemorrhagic stroke 2.2 (CI = 1.8-2.7) and ischaemic stroke 1.5 (CI = 1.3-1.7).
Several cancer sites/types are associated with an increased risk of haemorrhagic and ischaemic strokes.
癌症患者中中风较为常见，但不同癌症部位/类型的风险评估尚未确定。本项全国性研究旨在调查癌症与出血性或缺血性中风首次住院之间是否存在关联。
1987 年 1 月 1 日至 2008 年 12 月 31 日期间，瑞典所有诊断出患有癌症的 820491 人都接受了出血性或缺血性中风首次住院的随访。参考人群为瑞典所有无癌症人群。计算出血性和缺血性中风的标准化发病比（SIR）。
癌症确诊后 6 个月内，出血性中风和缺血性中风的总体风险分别为 2.2（95%置信区间（CI）= 2.0-2.3）和 1.6（CI = 1.5-1.6）。在所研究的 34 种癌症中的 18 种和 20 种癌症中，出血性和缺血性中风的风险分别增加。即使在癌症确诊 10 年后，总体中风风险仍迅速下降，但仍处于高位（出血性中风为 1.2（CI = 1.1-1.3），缺血性中风为 1.1（CI = 1.1-1.2））。诊断出癌症后，神经系统（出血性中风为 29（CI = 25-34），缺血性中风为 4.1（CI = 3.4-4.8））或白血病（出血性中风为 13（CI = 10-16），缺血性中风为 3.0（CI = 2.5-3.7））癌症的风险最高。转移与出血性中风风险增加相关（2.2（CI = 1.8-2.7））和缺血性中风（1.5（CI = 1.3-1.7））。
一些癌症部位/类型与出血性和缺血性中风的风险增加相关。
