School of Psychiatry and Clinical Neurosciences, University of Western Australia, 39 Gladstone Rd., Highgate Hill, Brisbane, QLD, Australia.
Cardiovasc Toxicol. 2012 Jun;12(2):149-57. doi: 10.1007/s12012-012-9154-2.
High-sensitivity C-reactive protein (hs-CRP) has been shown to be linked with immune stimulation, but is not well studied over the lifetime in opiate addiction. hs-CRP was measured by standard laboratory methods in substance use disorder (SUD) patients and non-SUD (NSUD) aged 18-48 years. Data were log transformed to improve normality. 1231 SUD were compared with 326 NSUD patients of comparable ages. hs-CRP was 7.46 ± 14.24 versus 4.75 ± 13.40 mg/l (mean ± SD) significantly higher in the SUD group (P < 0.0001), a difference which persisted after exclusion of acutely elevated hs-CRP values (P < 0.0001). In multiple regression with age, addictive status was significant both by itself (P < 0.0001) and in interaction with age (P < 0.0001). At age 40 years, the SUD group had a mean hs-CRP of 3.68 which the NSUD group did not achieve till a modelled age of 157.09 years. In an interactive multivariate regression, interactions between age, addictive status, ALT and AST were significant. These data show that hs-CRP is elevated in opiate dependence both per se, and when controlled for age. Furthermore, they suggest that hs-CRP and immune stimulation seen in opiate addiction may underlie the acceleration of age-related multi-system chronic and coronary atherosclerotic disease well described in opiate dependence.
高敏 C 反应蛋白（hs-CRP）与免疫刺激有关，但在阿片类药物成瘾的整个生命周期中尚未得到充分研究。通过标准实验室方法测量物质使用障碍（SUD）患者和年龄在 18-48 岁之间的非物质使用障碍（NSUD）患者的 hs-CRP。对数据进行对数转换以改善正态性。将 1231 名 SUD 患者与 326 名年龄匹配的 NSUD 患者进行比较。SUD 组的 hs-CRP 为 7.46±14.24mg/l，明显高于 NSUD 组（4.75±13.40mg/l）（P<0.0001），排除 hs-CRP 值急性升高后差异仍然存在（P<0.0001）。在年龄的多元回归中，成瘾状态本身（P<0.0001）和与年龄的相互作用（P<0.0001）均有统计学意义。在 40 岁时，SUD 组的平均 hs-CRP 为 3.68，而 NSUD 组要到模拟年龄 157.09 岁才达到这一水平。在交互多元回归中，年龄、成瘾状态、ALT 和 AST 之间的相互作用具有统计学意义。这些数据表明，hs-CRP 在阿片类药物依赖中既本身升高，又在控制年龄后升高。此外，它们表明，阿片类药物依赖中观察到的 hs-CRP 和免疫刺激可能是阿片类药物依赖中描述的与年龄相关的多系统慢性和冠状动脉粥样硬化疾病加速的基础。
