Decelis Stephen, Camilleri Simon, Zahra Ethel Vento, Scerri Erica, De Wever Bart
Pathology Department, Mater Dei Hospital, Msida, Malta.
Quintessence Int. 2012 Mar;43(3):239-45.
Candida colonization is a consequence of orthodontic treatment and can lead to oral candidosis as a complication of maxillary removable appliance treatment. During orthodontic treatment, it is important to minimize colonization to prevent active infection that could consequently interfere with treatment. Hygiene is the most important factor in managing colonization; in this study, the efficacy of NitrAdine to reduce Candida was tested.
A randomized, double-blind, placebo-controlled trial was performed. Ninety-two patients 11 to 14 years of age were recruited at the Children's and the University Dental Clinics at Mater Dei Hospital, Tal-Qroqq, Msida, Malta. Forty-four patients used the product with NitrAdine, while 48 patients used a placebo. Sampling employing the imprint technique was performed before and after the product was used. Brilliance Candida agar was used for cultures and identification. Further identification was performed using Auxacolor 2 when required.
The control group had a statistically significant increase in Candida during treatment, while the experimental group had a nonstatistically significant decrease.
It was concluded that NitrAdine may reduce the Candida burden in maxillary removable appliances. Larger sample sizes are needed to achieve statistical significance.
念珠菌定植是正畸治疗的一个后果，可导致口腔念珠菌病，成为上颌可摘矫治器治疗的一种并发症。在正畸治疗期间，尽量减少定植以预防可能干扰治疗的活动性感染非常重要。卫生是控制定植的最重要因素；在本研究中，测试了NitrAdine减少念珠菌的效果。
进行了一项随机、双盲、安慰剂对照试验。在马耳他姆西达塔尔 - 克罗克马特德伊医院的儿童牙科诊所和大学牙科诊所招募了92名11至14岁的患者。44名患者使用含NitrAdine的产品，而48名患者使用安慰剂。在使用产品前后采用印迹技术进行采样。使用 Brilliance念珠菌琼脂进行培养和鉴定。必要时使用Auxacolor 2进行进一步鉴定。
治疗期间，对照组念珠菌数量有统计学意义的增加，而实验组有非统计学意义的减少。
得出的结论是，NitrAdine可能减轻上颌可摘矫治器上的念珠菌负荷。需要更大的样本量才能达到统计学意义。
