Perelli Michele, Abundo Roberto, Semenza Mario, Centracchio Mauro, Chiara Stefano Di, Monaco Andrea, Arduino Paolo Giacomo
Departemnt of Periodontology, Private Practice, Torino, Italy.
Departemnt of Prosthodontist, Private Practice, Sant'Angelo Lodigiano, Italy.
Eur J Dent. 2022 Jul;16(3):612-618. doi: 10.1055/s-0041-1741120. Epub 2021 Dec 7.
This article aimed to evaluate the clinical efficacy of a nonantibiotic biofilm-removal formulation based on NitrAdine (PerioTabs), combined with a regular home oral hygiene regimen, in Caucasian patients with gingivitis.
A sample of 60 patients were included in this clinical prospective study. All selected subjects underwent regular prophylaxis and professional oral hygiene at baseline; 30 days later, they were recalled for the measurements of the reference parameters about bleeding on probing (full-mouth bleeding upon probing score [FMBS]) and plaque index (full-mouth plaque score [FMPS]); no other clinical procedure was performed. Consequently, half of the patients ( = 30) were instructed to use PerioTabs for 10 days. The remaining patients ( = 30) were used as the negative control, only instructed to continue with their usual oral hygiene regimen. Fifteen days after, the clinical parameters of FMBS and FMPS were re-evaluated in both groups.
Changes in the scores of clinical indices FMBS and FMPS were calculated and compared. A significant difference between pre- and post-values, for both FMBS and FMPS, was noticed in the test group; in particular, the bleeding index value demonstrated the more significant changes: 22 participants showed a clinically meaningful improvement, and 5 had a small improvement. Only three patients had no evidence of change. In addition, 50% of patients had a reduction in plaque levels. No side effects were reported.
The adjunctive use of 10-day PerioTabs treatment in the daily oral hygiene routine seemed to be efficient in reducing gingival bleeding and plaque accumulation, with absence of adverse effects. These results should be confirmed in studies with a larger number of participants following a controlled-blinded design.
本文旨在评估一种基于NitrAdine（PerioTabs）的非抗生素生物膜清除制剂联合常规家庭口腔卫生方案，对患有牙龈炎的白种人患者的临床疗效。
60名患者纳入该临床前瞻性研究。所有入选受试者在基线时均接受常规预防和专业口腔卫生护理；30天后，他们被召回测量探诊出血（全口探诊出血评分[FMBS]）和菌斑指数（全口菌斑评分[FMPS]）的参考参数；未进行其他临床操作。因此，一半患者（n = 30）被指示使用PerioTabs 10天。其余患者（n = 30）作为阴性对照，仅被指示继续其常规口腔卫生方案。15天后，对两组患者重新评估FMBS和FMPS的临床参数。
计算并比较临床指标FMBS和FMPS评分的变化。试验组FMBS和FMPS的前后值均有显著差异；特别是，出血指数值变化更为显著：22名参与者显示出有临床意义的改善，5名有轻微改善。只有3名患者无变化迹象。此外，50%的患者菌斑水平降低。未报告副作用。
在日常口腔卫生护理中辅助使用10天的PerioTabs治疗似乎能有效减少牙龈出血和菌斑积聚，且无不良反应。这些结果应在采用对照盲法设计、有更多参与者的研究中得到证实。
