Mohsen Amr
Department of Medicine, The George Washington University, Medical Center, Washington, DC 20037, USA.
Acta Cardiol. 2011 Dec;66(6):803-5. doi: 10.1080/ac.66.6.2136967.
Atrial fibrillation (AF) affects 2.3 million people in the United States and is currently the most common cardiac arrhythmia. Its overall prevalence is only increasing as the population ages. The classical risk factors for developing AF include hypertension, valvular disease, ischemic cardiomyopathy, and thyroid disease. In some patients with AF, an underlying cardiovascular pathology is not identified and the etiology remains unknown. Treatment modalities for AF typically include rate control medications, antiarrhythmics and radio frequency ablation (RFA), each of which is accompanied by its own risk of complications. We report a case of symptomatic AF that was refractory to multiple antiarrhythmics and an RFA procedure which resolved with prednisone. In this case, AF was associated with cardiac sarcoidosis, a disorder that is thought to be due to granulomatous involvement of the myocardium and increased systemic inflammation.
在美国，心房颤动（AF）影响着230万人，是目前最常见的心律失常。随着人口老龄化，其总体患病率正在上升。发生AF的经典危险因素包括高血压、瓣膜病、缺血性心肌病和甲状腺疾病。在一些AF患者中，未发现潜在的心血管病变，病因仍然不明。AF的治疗方式通常包括心率控制药物、抗心律失常药物和射频消融（RFA），每种治疗方式都伴有其自身的并发症风险。我们报告一例有症状的AF病例，该病例对多种抗心律失常药物和RFA治疗均无效，但使用泼尼松后病情得到缓解。在该病例中，AF与心脏结节病有关，心脏结节病是一种被认为由于心肌肉芽肿性受累和全身炎症增加所致的疾病。
