Department of Dermatology, Mint Wing A, St Mary's Hospital, London, UK.
Clin Exp Dermatol. 2012 Aug;37(6):649-51. doi: 10.1111/j.1365-2230.2011.04297.x. Epub 2012 Feb 2.
A 58-year-old woman presented with a 3-week history of a pruritic rash, which had started a week after commencing treatment with amlodipine. On physical examination, large, well-demarcated erythematous plaques, surrounded by small clusters of clear vesicles, were seen on the patient's torso. Subepidermal blisters with neutrophils and eosinophils were seen in a skin biopsy, and direct immunofluorescence showed deposition of IgA along the basement membrane, in keeping with a diagnosis of linear IgA dermatosis (LAD). Amlodipine was discontinued, and the patient was started on prednisolone 30 mg, supplemented shortly afterwards by dapsone, which resulted in prompt resolution of the rash. Only a few cases of drug-induced LAD have been reported, mostly in association with vancomycin. To our knowledge, this is the first reported case precipitated by amlodipine.
一位 58 岁女性因瘙痒性皮疹就诊，该皮疹于开始服用氨氯地平后 3 周出现，最初出现在躯干部。体格检查发现患者躯干上有大的、边界清楚的红斑斑块，周围有小簇透明水疱。皮肤活检显示表皮下水疱，其中有中性粒细胞和嗜酸性粒细胞，直接免疫荧光显示 IgA 沿基底膜沉积，符合线性 IgA 皮肤病（LAD）的诊断。停用氨氯地平，给予患者泼尼松龙 30mg，随后不久加用氨苯砜，皮疹迅速消退。仅有少数几例药物诱导的 LAD 被报道，主要与万古霉素有关。据我们所知，这是首例由氨氯地平引发的病例。
