Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Clin Exp Dermatol. 2012 Apr;37(3):296-9. doi: 10.1111/j.1365-2230.2011.04265.x. Epub 2012 Feb 2.
The protein lipocalin (LCN)-2 is known to be related to insulin resistance, obesity and atherosclerotic diseases. Psoriasis is an inflammatory skin disease related to metabolic syndrome. The aim of this study was to examine the relationship between serum LCN2 levels and indicators for metabolic syndrome and inflammatory cytokine levels in patients with psoriasis. Serum LCN2 levels were measured in patients with psoriasis, atopic dermatitis (AD) or bullous pemphigoid (BP), and compared with those of healthy controls. Serum LCN2 levels were also compared with several indicators for metabolic syndrome, and with serum levels of interleukin (IL)-6 and tumour necrosis factor (TNF)-α, two markers of inflammation. Serum LCN2 levels in patients with psoriasis were significantly higher than those of healthy controls, but there was no significant correlation between serum LCN2 and body mass index. Serum LCN2 levels also correlated with serum IL-6 and TNF-α levels in patients with psoriasis. Serum LCN2 levels are a general indicator for increased inflammation in the patients with psoriasis.
蛋白 lipocalin（LCN）-2 已知与胰岛素抵抗、肥胖和动脉粥样硬化疾病有关。银屑病是一种与代谢综合征相关的炎症性皮肤病。本研究旨在探讨银屑病患者血清 LCN2 水平与代谢综合征指标及炎症细胞因子水平的关系。测量了银屑病、特应性皮炎（AD）或大疱性类天疱疮（BP）患者的血清 LCN2 水平，并与健康对照组进行了比较。还比较了血清 LCN2 水平与代谢综合征的几个指标，以及两种炎症标志物——白细胞介素（IL）-6 和肿瘤坏死因子（TNF）-α 的血清水平。银屑病患者的血清 LCN2 水平明显高于健康对照组，但血清 LCN2 与体重指数之间无显著相关性。银屑病患者的血清 LCN2 水平与血清 IL-6 和 TNF-α 水平相关。血清 LCN2 水平是银屑病患者炎症增强的一般指标。
