Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt.
Arch Dermatol Res. 2014 Apr;306(3):239-45. doi: 10.1007/s00403-013-1414-x. Epub 2013 Sep 20.
Adipose tissue is now considered an endocrine organ secreting different cytokines known as adipocytokines. Lipocalin-2 has been recently identified as an adipokine present in the circulation, it is related to insulin resistance, obesity, atherosclerotic diseases and type 2 diabetes. Lipocalin-2 and psoriasis are assumed to be closely associated with the metabolic syndrome. The aim of the present study is to estimate the level of lipocalin-2 in the serum and tissue of psoriatic patients and to correlate these levels with markers of metabolic syndrome, CRP and disease severity. This study was done on 30 patients of psoriasis and 30 healthy controls. All patients and controls were subjected to clinical examination. Serum, tissue levels of lipocalin-2 and C-reactive protein (CRP) were measured by enzyme linked immunosorbent assay technique. Metabolic syndrome parameters including anthropometric measures, lipid profiles, blood sugar and blood pressure were studied. Patients with psoriasis showed significant association with metabolic syndrome parameters than controls. Tissue lipocalin-2 was significantly higher than serum levels in psoriasis patients. A significant difference was detected in tissue levels of lipocalin-2 and not in the serum between patients and controls. Both tissue and serum lipocalin-2 correlated with CRP. Although there was a correlation between tissue and serum levels of lipocalin-2 in patients, there was no correlation between both of them with metabolic syndrome and related disorders. Our results revealed that patients with psoriasis are at increased risk of metabolic and cardiovascular complications, tissue lipocalin-2 is more specific to psoriasis than serum lipocalin-2. Lipocalin-2 has no role in determining severity of the disease. Neither tissue nor serum lipocalin-2 conveys cardiovascular risk in psoriasis patients.
脂肪组织现在被认为是一种内分泌器官，分泌不同的细胞因子，称为脂肪细胞因子。脂联素-2 最近被确定为一种存在于循环中的脂肪因子，它与胰岛素抵抗、肥胖、动脉粥样硬化疾病和 2 型糖尿病有关。脂联素-2 和银屑病被认为与代谢综合征密切相关。本研究旨在评估银屑病患者血清和组织中脂联素-2 的水平，并将这些水平与代谢综合征标志物、C 反应蛋白（CRP）和疾病严重程度相关联。本研究共纳入 30 例银屑病患者和 30 例健康对照者。所有患者和对照者均接受了临床检查。采用酶联免疫吸附试验技术检测血清和组织中脂联素-2 和 C 反应蛋白（CRP）的水平。研究了代谢综合征的参数，包括人体测量学指标、血脂谱、血糖和血压。与对照组相比，银屑病患者与代谢综合征参数显著相关。银屑病患者的组织脂联素-2 明显高于血清水平。在患者和对照组之间，组织中脂联素-2 的水平存在显著差异，但血清中没有差异。组织和血清脂联素-2均与 CRP 相关。虽然患者的组织和血清脂联素-2 之间存在相关性，但它们与代谢综合征及其相关疾病之间均无相关性。我们的结果表明，银屑病患者发生代谢和心血管并发症的风险增加，组织脂联素-2 比血清脂联素-2 更特异于银屑病。脂联素-2 对疾病严重程度没有作用。无论是组织还是血清脂联素-2，在银屑病患者中均不能传递心血管风险。
