Department of Health Sciences, Section of Dermatology, Rare Dermatological Unit, Azienda USL Toscana Centro, University of Florence, 50125 Florence, Italy.
Unit of Epidemiology of Rare Diseases and Congenital Anomalies, Institute of Clinical Physiology, National Research Council, 56127 Pisa, Italy.
Int J Mol Sci. 2022 Oct 14;23(20):12291. doi: 10.3390/ijms232012291.
Background: Studies have demonstrated a higher risk of nonmelanoma skin cancers (NMSC) and a modestly increased melanoma risk in patients with psoriasis. To date, no biomarkers predictive of evolution have been identified yet. Methods: The aim of this prospective case-control study was to investigate the potential role of neutrophil gelatinase-associated lipocalin (NGAL) as a predictive biomarker of skin cancers in psoriatic patients. Patients with a diagnosis of psoriasis were enrolled, as well as healthy subjects and patients with skin cancers as controls. Plasma protein expression of NGAL, metalloproteinases (MMP)-2, and MMP-9 was performed by an enzyme-linked immunosorbent assay (ELISA). In all the patients who developed skin cancer at follow-up, NGAL, MMP-2, and MMP-9 serum levels were dosed again. Results: Plasma NGAL levels were significantly higher in psoriatic patients with NMSC than without (182.3 ± 36.6 ng/mL vs. 139.9 ± 39.3 ng/mL) (p < 0.001). Plasma NGAL levels were significantly higher (p < 0.00001) in patients with psoriasis and NMSC than in patients with skin tumors without psoriasis (182.3 vs. 122.9). Patients with psoriasis who developed NMSC at follow-up showed increased plasma MMP-9 levels. Conclusion: NGAL seems to play a role in the pathogenesis of NMSC but not melanoma in patients with psoriasis.
研究表明，银屑病患者发生非黑素瘤皮肤癌（NMSC）的风险较高，且患黑色素瘤的风险也略有增加。迄今为止，尚未发现可预测疾病进展的生物标志物。方法：本前瞻性病例对照研究旨在探讨中性粒细胞明胶酶相关脂质运载蛋白（NGAL）作为预测银屑病患者皮肤癌的潜在生物标志物的作用。招募了银屑病患者，并选择健康对照者和皮肤癌患者作为对照。通过酶联免疫吸附试验（ELISA）检测 NGAL、基质金属蛋白酶（MMP）-2 和 MMP-9 的血浆蛋白表达。对所有在随访中发生皮肤癌的患者，再次检测 NGAL、MMP-2 和 MMP-9 的血清水平。结果：发生 NMSC 的银屑病患者的血浆 NGAL 水平明显高于未发生 NMSC 的患者（182.3 ± 36.6 ng/mL 比 139.9 ± 39.3 ng/mL）（p < 0.001）。银屑病合并 NMSC 患者的血浆 NGAL 水平明显高于无银屑病的皮肤肿瘤患者（182.3 比 122.9）（p < 0.00001）。在随访中发生 NMSC 的银屑病患者的血浆 MMP-9 水平升高。结论：NGAL 似乎在银屑病患者的 NMSC 发病机制中起作用，但对黑色素瘤无作用。
