García-Mayor Ricardo V, Larrañaga Vidal Alejandra, Docet Caamaño Maria F, Lafuente Giménez Anunciación
Unidad de Investigación Compartida «Obesógenos» Sergas, Servicio de Endocrinología, Diabetes, Nutrición y Metabolismo, Universidad de Vigo, Vigo, España.
Endocrinol Nutr. 2012 Apr;59(4):261-7. doi: 10.1016/j.endonu.2011.11.008. Epub 2012 Feb 1.
Incidence and prevalence of owerweight and obesity have greatly increased over the past three decades in almost all countries around the world. This phenomenon is not easily explained by lifestyle changes in populations with very different initial habits. This has led to consider the influence of other factors, the so-called endocrine disruptors, and more specifically obesogens. This study reviewed the available evidence about polluting chemical substances which may potentially be obesogens in humans: DES, genistein, bisphenol A, organotins (TBT, TPT), and phthalates. The first three groups of substances mainly act upon estrogen receptors, while organotins and phthalates activate PPARγ. It was concluded that evidence exists of the obesogenic effect of these chemical substances in tissues and experimental animals, but few data are available in humans.
在过去三十年里，全球几乎所有国家超重和肥胖的发病率及患病率都大幅上升。对于初始习惯差异极大的人群而言，这种现象难以单纯用生活方式的改变来解释。这促使人们考虑其他因素的影响，即所谓的内分泌干扰物，更具体地说是致肥胖物。本研究回顾了有关可能对人类具有潜在致肥胖作用的污染化学物质的现有证据：己烯雌酚、染料木黄酮、双酚A、有机锡（三丁基锡、三苯基锡）和邻苯二甲酸盐。前三类物质主要作用于雌激素受体，而有机锡和邻苯二甲酸盐则激活过氧化物酶体增殖物激活受体γ（PPARγ）。研究得出结论，这些化学物质在组织和实验动物中存在致肥胖作用的证据，但关于人类的数据却很少。
