Department of Pediatrics, Division of Endocrinology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Curr Opin Endocrinol Diabetes Obes. 2013 Feb;20(1):50-5. doi: 10.1097/MED.0b013e32835b7ee6.
This review describes the most recent data about the effects of endocrine disrupting compounds (EDCs) on infant and early childhood growth and reproductive tract development as well as controversies in the field.
EDCs are present in pregnant women, young children and adolescents. Whether the level of exposure contributes to disease is an ongoing debate. Epidemiological studies suggest associations between prenatal EDC exposure and disease outcome, but animal studies using controlled EDC exposure have varying results with underlying mechanisms largely unknown.
Human exposure to EDCs is widespread; bisphenol A, phthalates and persistent organic pollutants are detectable in all age groups and geographical locations in the USA. Epidemiological and animal studies suggest that phthalates and bisphenol A have adverse effects on birth weight, promote development of childhood obesity and adversely affect male reproductive tract development. Differences in the interpretation of available studies underlie the disparate conclusions of scientific and regulatory body's panels on potential toxicological effects of EDCs at current levels of human exposure.
本文描述了关于内分泌干扰化合物 (EDCs) 对婴幼儿生长和生殖道发育的最新影响的数据，以及该领域的争议。
EDCs 存在于孕妇、婴幼儿和青少年体内。接触水平是否会导致疾病仍存在争议。流行病学研究表明，产前 EDC 暴露与疾病结果之间存在关联，但使用受控 EDC 暴露的动物研究结果存在差异，其潜在机制在很大程度上尚不清楚。
人类接触 EDCs 的现象普遍存在；双酚 A、邻苯二甲酸盐和持久性有机污染物在美国所有年龄段和地理位置都可检测到。流行病学和动物研究表明，邻苯二甲酸盐和双酚 A 对出生体重有不良影响，会促进儿童肥胖的发展，并对男性生殖道发育产生不良影响。对现有研究的不同解释是造成科学界和监管机构小组对人类目前接触 EDC 水平的潜在毒理学效应得出不同结论的基础。
