Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain.
J Virol. 2012 Apr;86(7):3617-25. doi: 10.1128/JVI.07108-11. Epub 2012 Feb 1.
Worldwide amphibian population declines have been ascribed to global warming, increasing pollution levels, and other factors directly related to human activities. These factors may additionally be favoring the emergence of novel pathogens. In this report, we have determined the complete genome sequence of the emerging common midwife toad ranavirus (CMTV), which has caused fatal disease in several amphibian species across Europe. Phylogenetic and gene content analyses of the first complete genomic sequence from a ranavirus isolated in Europe show that CMTV is an amphibian-like ranavirus (ALRV). However, the CMTV genome structure is novel and represents an intermediate evolutionary stage between the two previously described ALRV groups. We find that CMTV clusters with several other ranaviruses isolated from different hosts and locations which might also be included in this novel ranavirus group. This work sheds light on the phylogenetic relationships within this complex group of emerging, disease-causing viruses.
全球范围内的两栖动物种群数量下降归因于全球变暖、污染水平的不断提高以及其他与人类活动直接相关的因素。这些因素可能还会助长新型病原体的出现。在本报告中，我们确定了新兴的普通蟾蜍蛙病毒（CMTV）的完整基因组序列，该病毒已在欧洲的几种两栖动物物种中引起致命疾病。对欧洲分离出的首例 Ranavirus 完整基因组的系统发育和基因含量分析表明，CMTV 是一种类似于两栖动物的 Ranavirus（ALRV）。然而，CMTV 的基因组结构是新颖的，代表了先前描述的两种 ALRV 组之间的一个中间进化阶段。我们发现，CMTV 与从不同宿主和地点分离的其他几种蛙病毒聚类，这些蛙病毒也可能被归入这一新的蛙病毒组中。这项工作揭示了该新兴致病病毒复杂群体内的系统发育关系。
